Technical Resources - Cell Line Database

Cell Lines Detail

Cell Line Name:

B-TC3

Organism Type:

Mouse

Tissues:

Pancreas

Adherence Phenotype:

Adherent

Primary:

No

Scientific Application(s):

Transient Transfection

Comments:

The pancreatic beta-cell line has been established from insulinomas derived from transgenic mice carrying a hybrid insulin-promoted simian virus 40 tumor antigen gene. The cells produce both proinsulin I and II and efficiently process each into mature insulin, in a manner comparable to normal beta cells in isolated islets. Insulin secretion is inducible up to 30-fold by glucose, although with a lower threshold for maximal stimulation than that for normal beta cells.

 

Products and applications for " B-TC3 "
Transfection Display 1