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Molecular characteristics of components of the oxidative phosphorylation system - Table 12.5

Complex Name Molecular Weight * Alternative Name Protein Number † Gene Number ‡
I NADH–ubiquinone oxidoreductase 39,000-dalton subunit 42.5 α subcomplex, 9 Q16795 NDUFA9
30,000-dalton subunit 30.2 iron–sulfur protein 3 O75489 NDUFS3
20,000-dalton subunit  20.0 ND6 protein (NDU subunit 6) P03923 MTND6
17,000-dalton subunit 15.5 β subcomplex, 6 O95139 NDUFB6
15,000-dalton subunit 15.1 α subcomplex, 6 P56556 NDUFA6
II Succinate–ubiquinone oxidoreductase 70,000-dalton subunit 72.7 flavoprotein P31040 SDHA
30,000-dalton subunit 31.6 iron–sulfur protein P21912 SDHB
III Ubiquinone–cytochrome c oxidoreductase Core 1 subunit 51.6 none P31930 UQCRC1
Core 2 subunit 48.5 none P22695 UQCRC2
Iron–sulfur subunit 29.6 Rieske iron–sulfur protein P47985 UQCRFS1
10,000-dalton subunit 9.6 § subunit VII P13271 § UCRQ
IV Cytochrome c oxidase (COX) Subunit I 57.0 COX I P00395 MTCO1
Subunit II 25.6 COX II P00403 MTCO2
Subunit III 29.9 COX III P00414 MTCO3
Subunit IV 19.6 COX IV P13073 COX4
Subunit Va 16.8 COX Va P20674 COX5A
Subunit Vb 13.7 COX Vb P10606 COX5B
Subunit VIa-L ** 9.5 § COX VIa P13182 § COX6A1
Subunit VIb 10.0 § COX VIb P00429 § COX6B
Subunit VIc 8.8 COX VIc P09669 COX6C
Subunit VIIa-H/L ** 9.4 COX VIIa P14406 COX7A2
Subunit VIIb 9.2 COX VIIb P24311 COX7B
V ATP synthase α subunit 59.8 F1 complex, α subunit P25705 ATP5A1
β subunit 56.6 F1 complex, β subunit P06576 ATP5B
d subunit 18.4 none O75947 ATP5H
OSCP subunit †† 23.2 F1 complex, O subunit P48047 ATP5O
Inhibitor protein (IP) 12.3 § IF1 P01096 § ATPI
* Molecular weight in kilodaltons. † Protein reference numbers are from SWISS-PROT, an annotated protein sequence database (http://www.ebi.ac.uk/swissprot/) and refer to the human sequence, unless otherwise noted. ‡ Gene reference numbers are from Genbank, which can be accessed through Entrez (http://www3.ncbi.nlm.nih.gov/Entrez/). § Protein number and molecular weight are for the bovine sequence. **[ H = heart-specific isotope; L = liver-specific isotope. †† OSCP = oligomycin sensitivity–conferring protein.