- Ambion® Pre-miR™ miRNA Precursors are chemically modified dsRNA molecules designed to mimic mature miRNA molecules. They enable functional analysis of individual microRNAs via gain-of-function experiments. Ambion® Anti-miR™ miRNA Inhibitors are chemically modified, single stranded nucleic acids designed to specifically bind to and inhibit mature miRNA molecules. They enable detailed study of miRNA biological effects via reduction-of-function experiments.
Ambion® Pre-miR™ miRNA PrecursorsThese ready-to-use miRNA mimics have been carefully designed and modified to ensure that the correct strand, representing the desired mature miRNA, is taken up into RISC. Thanks to their small size, they are easier to transfect than vectors, and can be delivered using conditions identical to those used for siRNAs.
Use of Pre-miR™ miRNA Precursors enable miRNA functional analysis by up-regulation of miRNA activity. Specific experimental designs include miRNA target site identification and validation, screening for miRNAs that regulate the expression of a gene, and screening for miRNAs that affect a cellular process.
Pre-miR™ miRNA Precursors are available for mimicking each of the human, mouse, and rat mature miRNAs cataloged in the Sanger miRBase Sequence database.
NOTE: Pre-miR™ miRNA Precursors are not hairpin constructs and should not be confused with pre-miRNAs.Ambion® Anti-miR™ miRNA InhibitorsThese ready-to-use inhibitors, which are modified to enhance inhibition efficiency as well as to improve nucleic acid stability during delivery, can be introduced into cells using transfection or electroporation parameters similar to those used for siRNAs. Use of Anti-miR™ miRNA Inhibitors enable miRNA functional analysis by down-regulation of miRNA activity.
Anti-miR™ miRNA Inhibitors are available for inhibiting each of the human, mouse, and rat mature miRNAs cataloged in the Sanger miRBase Sequence database.
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Custom Ambion® Pre-miR™ miRNA Precursors & Anti-miR™ miRNA Inhibitors
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