The Silencer® Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry. A choice of Silencer® Select siRNAs are available—Pre-Designed or Validated. Silencer® Select Pre-Designed siRNAs are guaranteed-to-silence based on their proven design while the Silencer® Select Validated siRNAs are functionally
tested to reduce target gene expression. Sets of Silencer® Select siRNA Libraries are also available in tubes or plate for high throughput screening. The Silencer® Select Positive and Negative Control RNAs should be included in every siRNA experiment.
The benefits of using Silencer® Select siRNAs include:
- Potent—up to 100-fold more potent than currently available siRNAs and fewer off-target effects
- Most Specific—LNA® chemical modifications reduce off-target effects by up to 90%
- Reliable—demonstrated improvements in consistency and reliability of phenotypic results
- Guaranteed—100% guaranteed to silence, the best guarantee in the industry
Note: Silencer® Pre-Designed & Validated siRNAs are designed using our first-generation algorithm and DO NOT include any chemical modifications. They are recommended for completing in vitro RNAi studies that were started using Silencer® siRNAs.
For new studies we recommend Silencer Select siRNAs.
Approximate Turnaround Times*
Standard purification: 4 business days
HPLC purification: 6 business days (20 and 40 nmol); 15 business days (250 nmol)
In Vivo Ready: 15 business days (250 nmol)
| Catalog # |
Pre-designed/Validated |
Purification |
Size |
| 4390817 | Pre-designed | HPLC purified | 20 nmol |
| 4390818 | Pre-designed | HPLC purified | 40 nmol |
| 4404014 | Pre-designed | HPLC purified | 250 nmol |
| 4404010 | Pre-designed | In Vivo Ready | 250 nmol |
| 4390815 | Pre-designed non-inventoried | Standard purity | 20 nmol |
| 4390771 | Pre-designed non-inventoried | Standard purity | 5 nmol |
| 4390816 | Pre-designed non-inventoried | Standard purity | 40 nmol |
| 4392420 | Pre-designed | Standard purity | 5 nmol |
| 4392421 | Pre-designed | Standard purity | 20 nmol |
| 4392422 | Pre-designed | Standard purity | 40 nmol |
| 4427037 | Pre-designed | Standard purity | 1 nmol |
| 4390821 | Validated | HPLC purified | 20 nmol |
| 4390822 | Validated | HPLC purified | 40 nmol |
| 4407270 | Validated | HPLC purified | 250 nmol |
| 4407267 | Validated | In Vivo Ready | 250 nmol |
| 4390824 | Validated | Standard purity | 5 nmol |
| 4390825 | Validated | Standard purity | 20 nmol |
| 4390826 | Validated | Standard purity | 40 nmol |
| 4427038 | Validated | Standard purity | 1 nmol |
*Estimated time from order confirmation to ship date from Austin, TX for orders confirmed by 2 pm CST. Does not include time required for shipping (typically overnight for US and Canada deliveries, 2 days for Europe, 2-3 days elsewhere).
