Ambion® In Vivo Pre-designed siRNAs

Ambion® In Vivo siRNA molecules are chemically modified, 21-mer, double-stranded siRNAs that are recognized by the RNA-induced silencing complex (RISC) to mediate inhibition of a target gene. Proprietary chemical modifications allow Ambion® In Vivo siRNAs to overcome many in vivo–specific obstacles, ensuring their effectiveness and stability in vivo. Ambion® In Vivo siRNAs are at least 100x more stable in 90% mouse serum than unmodified siRNAs.

Ambion® In Vivo siRNAs, the new standard for in vivo RNAi applications, offer:

• High stability against nucleases
• No induction of the interferon response
• Easy tracking of administered siRNAs
• Combined knockdown effectiveness and stability