In Vivo RNAi

A solution for successful in vivo RNAi

In vivo RNAi experiments are more challenging than their in vitro counterparts due to the demands of the cellular environment. These added challenges necessitate the use of the highest-quality materials to obtain meaningful results. Invitrogen offers a complete solution for successful in vivo RNAi experiments including the highest quality chemically modified siRNA.

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New Ambion® In Vivo siRNA

Chemically modified RNAi duplexes for specificity, stability, and effective knockdown

Ambion® In Vivo siRNAs, the new standard for RNAi applications, offer:

  • High stability against nucleases
  • No induction of the interferon response
  • Easy tracking of administered siRNAs
  • Combined knockdown effectiveness and stability

Ambion® In Vivo siRNA molecules are chemically modified, 21-mer double-stranded siRNAs that are recognized by the RNA-induced silencing complex (RISC) to mediate inhibition of a target gene. Proprietary chemical modifications allow Ambion® In Vivo siRNAs to overcome many in vivo–specific obstacles, ensuring their effectiveness and stability in vivo. Ambion® In Vivo siRNAs are at least 100x more stable in 90% mouse serum than unmodified siRNAs.

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in vivo RNAi Research Considerations


Learn more about experimental considerations and leading techniques.

Stealth RNAi™ siRNA - in vivo-ready duplexes

Stealth RNAi™ siRNA overcomes many  in vivo-specific obstacles, ensuring effectiveness and stability in in vivo applications.
  • High stability against nucleases
  • No induction of the interferon response
  • Easy tracking of administered RNAi duplexes
  • Knockdown effectiveness and stability
  • Award-winning design algorithm
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