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For the past 16 years, Life Technologies has led the way in the evolution of STR technology. And today, GlobalFiler™ Kits |
Why 6-Dye?
Squeezing all the additional loci into a 5-dye configuration would result in multiple tradeoffs, including:
Tradeoff #1: Multiple loci in the high molecular weight size range (>400 bp), increasing drop out with degraded and challenging samples.
Tradeoff #2: Several loci extending almost to 500 bp, which may cause issues with sizing and resolution, i.e. alleles labeled “OL” or failure to resolve microvariant alleles.
Tradeoff #3: Fewer miniSTRs. The GlobalFiler™ Kits include 10 STRs completely under 220 bp! This would not be possible in a 5-dye configuration.
Tradeoff #4: Insufficient spacing between adjacent markers; more difficult to expand marker ranges to minimize “OL” allele calls.
Tradeoff #5: Many loci would require redesigned primer sequences, leading to less concordance with data generated using the original primer sequences and with the vast majority of profiles in worldwide databases.
For Forensic or Paternity use only. Not intended for any animal or human therapeutic or diagnostic use. © 2012 Life Technologies Corporation. All rights reserved. The trademarks mentioned herein are the property of Life Technologies Corporation or their respective owners, unless otherwise noted.
