GPCR Toxicity Panel
| Avoid off target effects with our GPCR toxicity panel Invitrogen offers a wide panel of well validated cellular assays for screening for selectivity (Table 1) among family members in addition to assays against receptors that currently have marketed drugs directed towards them. These cellular assays have been built using our powerful GeneBLAzer® beta-lactamase technology, and are available either as dividing cells or in our new Division Arrest (DA) format. |
Table 1 - GPCR Liability Panel
| Receptor | Dividing Cells | Division Arrested Assay Kit |
|---|---|---|
| 5HT1a | K1083 | K1317 |
| ADORA2A | K1245 | K1345 |
| ADRA2A | K1290 | K1343 |
| AVPR1A | K1286 | K1323 |
| CCKBR | K1231 | K1379 |
| CNR1 | K1267 | K1316 |
| CRHR1 | K1263 | K1367 |
| CRHR2 | K1262 | K1361 |
| D1 | K1086 | K1311 |
| D2 | K1232 | K1309 |
| EDG3 | K1234 | K1319 |
| EDG7 | K1251 | K1315 |
| EDNRA | K1223 | K1347 |
| EDNRB | K1224 | K1349 |
| H1 | K1225 | K1299 |
| H2 | K1226 | K1307 |
| HTR7 | K1264 | K1301 |
| M1 | K1230 | K1365 |
| M4 | K1235 | K1377 |
| VPAC1 | K1215 | K1303 |
