ADME/Tox

Invitrogen offers a collection of in vitro ADMETox tools for drug discovery and development, including GIBCO® hepatocytes, microsomes, and transporter products to help you determine the metabolic and safety profiles of lead candidates.

ADME/Tox Products

GIBCO® Hepatocytes

Fresh human & animal, cryopreserved human & animal, and cell culture reagents

Transporter Products

GenoMembrane Transporter Vesicles and Transporter-qualified Hepatocytes

Toxicology Products

Assays to identify indicators of both biochemical and cellular toxicity

Nuclear Receptor ADME Assays

Our LanthaScreen® PXR (SXR) and CAR Competitive Binding Assays contains all the reagents you need to conduct compound affinity testing

PCR-Based Drug Discovery Assays

Analyze drug discovery-related genes using our real-time PCR arrays

Hepatic Systems

HepaRG™ cells, hepatic co-cultures and non-parenchymal cell products

Liver Microsomes

Large pooled lots for long-term studies tested for select CYP450 & phase II enzyme activities

P450 Assays

Fluorescent substrates and recombinant enzymes to evaluate your compound’s potential impact on P450 activity

hERG Assays

Perform cardiac safety screening with biochemical or cellular assays to identify potential hERG channel blockers

G-Protein Coupled Receptor Cellular ADME Assays

Avoid off-target effects with our GPCR toxicity panel of validated cellular assays for selectivity screening

For Research Use Only. Not for use in diagnostic procedures.

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