Meet Your New Research Companion in Pharmacogenomics
Recent advances in genetic analysis have been exponential, leading to an expanded understanding of drug efficacy based on unique individual genomic makeup. Gold-standard TaqMan® genotyping associated with OpenArray® technology combines sample throughput, flexibility, and cost effectiveness that you can’t get with other technologies. Here, you’ll find a complete, scalable solution for your genotyping experiments as well as broad application choices. Meet your new pharmacogenomics companion today.
DME and SNP assays
For analysis of biologically important polymorphisms in drug metabolism, we offer 2,700 unique TaqMan® DME Assays that detect polymorphisms in regulatory elements, as well as coding regions in 221 drug metabolism enzyme (DME) and drug transporter genes.
Option 1: TaqMan® OpenArray® PGx Panel
The TaqMan® OpenArray® PGx Panel provides valuable data for studying drug interactions in several research areas. Targeted genes relate to areas of study such as cardiology/hematology (CYP2D6, CYP2C19, NAT1, NAT2), analgesics (CYP2C9, CYP2D6), rheumatology (CYP2C9, TPMT), neurology (CYP2C19, CYP2D6), and myology/osteology (CYP2C19). A total of 29 genes are covered across 158 unique assays.
Option 2: Design your own OpenArray® Panel
Option 3: Custom plating
TaqMan® DME Assays and TaqMan® SNP Genotyping assays are provided in lower throughput format:
- single-tube format
- custom plating option to design the 96- or 384-well plate of your choice
- custom TaqMan® Array Card for 384-well
Even if you just have a few samples to analyze, there is a TaqMan® Assay format to fir your research needs.
Copy Number Variation
Copy number variation (CNV) is an important polymorphism associated with drug metabolism and a number of diseases. Life Technologies offers over 1.6 million individual predesigned TaqMan® Copy Number Assays with human genome-wide coverage, targeting gene exons and introns, extragenic regions, and CNV sequences from the Database of Genomic Variants (DGV). TaqMan® Copy Number Assays are available as individual assays or in 96- and 384-well format with our custom plating option. Custom and Custom Plus TaqMan® Copy Number Assays offer an alternative CNV analysis solution when a predesigned assay for your target is not available.
QuantStudio™ 12K Flex Real-Time PCR System
Combining flexible throughput capabilities with a streamlined workflow, the QuantStudio™ 12K Flex system takes you from targeted discovery through confirmation and screening, all on a single platform.
OpenArray® technology is a broadly applicable nanoliter fluidics platform for low-volume, solution-phase reactions. OpenArray® technology benefits include:
Whether you need installation qualification and operation qualification (IQ/OQ) or instrument performance verification (IPV), our qualification services help you get audit-quality data to share with your regulated body and verify that your instrument is working according to manufacturer’s specifications.