How ChargeSwitch® Works

Figure 1. The ChargeSwitch® Technology features a charged nucleic acid–binding surface that is “switchable” by changing the pH of the surrounding buffer. At low pH, the surface is positively charged and binds the negatively charged nucleic acid backbone, allowing proteins and other contaminants to be washed away. The microplates included in the ChargeSwitch® Direct 96 gDNA Kit are coated with this unique, acid-binding, ChargeSwitch® surface.