JAK-STAT
To find antibodies, assays, and proteins associated with the JAK-STAT pathway, click on the icon for your desired gene of interest or follow the links below. Powered by Linnea™ Guide to Genes. View the gene lists for: Request Free Signaling Posters and Download Graphics Read more about JAK-STAT |
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Intracellular Proteins
| Gene Symbol | ||
|---|---|---|
| BAX | MAP1 | SMAD6 |
| BCL2 | MAP3 | SMAD7 |
| CREBBP | MYC | SOCS1 |
| CUL2 | NFKB1 | SOCS2 |
| EP300 (p300) | PIAS1 | SOCS3 |
| FOS | PIK3C3 | SP1 |
| GRB2 | PIK3CA | STAT1 |
| HRAS | PIK3CB | STAT2 |
| ISGF3G (IRF9) | PIK3CD | STAT3 |
| JAK1 | PIK3R1 | STAT4 |
| JAK2 | PTPN11 (Shp2) | STAT5A |
| JAK3 | RAF1 | STAT5B |
| JUN | RBX1 | STAT6 |
| KPNA1 (NPI-1) | RELA (NFκB) | SUMO1 |
| MAP2K1 | ROS1 | SUMO2 |
| MAP2K2 | SMAD1 | SUMO3 |
| MAP2K3 | SMAD2 | THPO (TPO) |
| MAP2K4 | SMAD3 | UBB |
| MAP2K5 | SMAD4 | UBE21 |
| MAP2K6 | SMAD5 | |
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Membrane Receptors
| Gene Symbol | ||
|---|---|---|
| ALK | F2R (Par1) | KDR (CD309) |
| AXL (UFO) | F2RL2 | KIT (CD117) |
| BTK | FGFR1 (CD331) | MERTK |
| CD2 | FGFR2 (CD332) | MET |
| CD4 | FGFR3 (CD333) | MST1R (CD136) |
| CD80 | FGFR4 (CD334) | MUSK |
| CSF1R (CD115) | FLT1 | NGFR (CD27)1 |
| CXCR4 (CD184) | FLT3 (CD135) | NTRK1 |
| DDR2 | FLT4 | NTRK2 |
| EGFR | IFNAR1 | NTRK3 |
| EPHA1 | IFNAR2 (CD118) | PDGFRA (CD140a) |
| EPHA2 | IFNGR1 (CD119) | PDGFRB (CD140b) |
| EPHA3 | IGF1R (CD221) | PRLR |
| EPHA4 | IL1R1 (CD121a) | ROR2 |
| EPHA5 | IL2RA (CD25) | TEK |
| EPHA7 | IL2RG (CD132) | TNFRSF10A (CD120a) |
| EPHA8 | IL3RA (CD123) | TNFRSF10B (CD262) |
| EPHB1 | IL4R (CD124) | TNFRSF1A (CD120a) |
| EPHB2 | IL6R (CD126) | TNFRSF1B (CD120b) |
| EPHB3 | IL12BR | TNFRSF25 (DR3) |
| EPHB4 | IL13RA (CD213A1) | TYRO3 |
| ERBB2 (Her2) | INSR (CD220) | |
| ERBB4 (Her4) | INSRR | |
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Cytokine Proteins
| Gene Symbol | ||
|---|---|---|
| ANGPT1 | FGF1 | IL5 |
| ANGPT2 | FGF2 | IL6 |
| ANGPT4 | FGF3 | IL7 |
| BMP2 | FGF4 | IL8 |
| BMP7 | FGF5 | IL9 |
| CCL2 (MCP1) | FGF6 | IL10 |
| CCL3 (MIP-1α) | FGF7 | IL11 |
| CCL4 (MIP-1β) | FGF8 | IL12A |
| CCL5 (RANTES) | FGF9 | IL12B |
| CCL7 (MCP-3) | FGF10 | IL13 |
| CCL8 (MCP-2) | FGF16 | IL15 |
| CCL11 (Eotaxin) | FGF17 | IL16 |
| CCL13 (MCP4) | FGF19 | IL17A |
| CCL15 (MIP-5) | GH1 | IL18 |
| CCL17 (TARC) | IFNA1 | IL19 |
| CCL18 (MIP-4) | IFNA2 | IL20 |
| CCL19 (MIP-3β) | IFNB1 | IL23A |
| CCL20 (MIP-3α) | IFNG | PRL |
| CCL21 (6Ckine) | IL1A | TNFSF10 (TRAIL) |
| CCL25 (TECK) | IL1B | TNFSF13B (BAFF) |
| CXCL12 (SDF1) | IL2 | VEGFA |
| EGF | IL3 | VEGFC |
| EPO | IL4 | |
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Technical Resources
- View our recent publication in "Assay and Drug Development Technologies". Cellular LanthaScreen and β-lactamase Reporter Assays for High-Throughput Screening of JAK2 Inhibitors
- Measuring proteins in JAK-STAT signaling
- Simultaneous Measurement of STAT1, STAT3, and STAT5a/b Activations in Response to Interferons by Multiplex Bead Immunoassay
- Cell Based and Biochemical Assay Tools for the Discovery of JAK Inhibitors