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Cell & Tissue Analysis

Signaling Pathways

cell signaling Empower your research today using Invitrogen’s comprehensive portfolio of products and services to investigate cell signaling pathways and signal transduction—everything from high quality reagents for basic research and assay development, validated biochemical and cell-based assays, and world-class profiling and screening services.

Akt

Akt Signaling Pathway

Currently, Akt and the Akt signaling pathway is one of the most actively studied kinases or kinase pathways in both the basic research and drug development arenas.

  • Learn More about Akt

Integrin

Integrin Signaling Pathway

Interactions between integrins and the extracellular matrix mediate intracellular signaling mechanisms to regulate cell survival, differentiation, cell cycle progression, and inflammatory responses. We offer a broad range of gene-specific products for studying integrin cell signaling and signal transduction.




Interferon (IFN)

Interferon (IFN) Signaling Pathway

Following viral infection, the human body triggers a complex regulatory system of innate and adaptive immune responses designed to defend against these foreign invaders.  One of the many responses to the viral invasion is the induction of a family of pleiotropic cytokines known as Interferons (IFN). Find antibodies, assays, and proteins associated with the Interferon (IFN) signaling pathway.




JAK-STAT

JAK-STAT Signaling Pathway

The janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in the signaling of a wide array of cytokines and growth factors leading to various cellular functions, including proliferation, growth, hematopoiesis, and immune response.


Mitogen Activated Protein Kinase (MAPK)

MAPK Signaling Pathway

The mitogen-activated protein kinase (MAPK) pathway mediates signal transduction from cell surface receptors to downstream transcription factors that lead to cellular responses such as cell proliferation, growth, motility, survival and apoptosis. The role of MAPK pathway in cancer, immune disorders and neurodegenerative diseases has been well recognized.

T-Cell Receptor (TCR)

T-Cell Receptor (TCR) Signaling Pathway

The T-Cell Receptor (TCR) is a complex of integral membrane proteins that participates in the activation of T-Cells in response to the presentation of antigen. Stimulation of TCR is triggered by MHC (Major Histocompatibility Complex) molecules on Antigen Presenting Cells that present antigen peptides to TCR complexes and induce a series of intracellular signaling cascades.

Toll-like Receptor (TLR)

Toll-like Receptor (TLR) Signaling Pathway

Toll-like receptor (TLR) signaling plays an essential role in the innate immune response. Activation of TLR signaling through recognition of pathogen-associated molecular patterns leads to the transcriptional activation of genes encoding for pro-inflammatory cytokines, chemokines and co-stimulatory molecules, which subsequently control the activation of antigen-specific adaptive immune response.




Tumor Necrosis Factor (TNF)

Tumor Necrosis Factor (TNF) Signaling Pathway

Tumor Necrosis Factor (TNF) superfamily of cytokines represents a multifunctional group of proinflammatory cytokines which activate signaling pathways for cell survival, apoptosis, inflammatory responses, and cellular differentiation.

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