New Antibodies for Flow Cytometry
Life Technologies offers a wide assortment of antibodies for your everyday flow cytometry research. Here you will find the newest antibodies released specifically for flow cytometry. Check back each month as we will continually list the latest antibodies released for flow cytometry.
New Hu CD137 Conjugates for Flow Cytometry
What’s new?Four new conjugates are now available for the human CD137 marker.
The mouse anti-human CD137 (4-1BB) monoclonal antibody (mAb) reacts with human CD137, which is expressed on dendritic cells, granulocytes, mast cells, T cells, and natural killer cells. CD137 is a member of the tumor necrosis factor receptor (TNFR) family of co-stimulatory molecules; and it is involved in recruiting TNFR-associated factors (TRAF), in activating T cells (specifically maintaining the survival of activated, CD8 memory T cells), in suppressing of myelopoiesis, and in developing dendritic cells. Ex vivo studies show that stimulating CD137 promotes expansion of CD4+CD25+ T regulatory cells. Its ligand, 4-1BBL, is found on hematopoietic stem cells, myeloid progenitor cells, activated macrophages, and mature B cells.
Figure 1. Two-color analysis of CD137 expression on normal human peripheral blood cells. Staining of 2-day ConA-stimulated normal human peripheral blood cells with an anti-human CD69-APC antibody and a mouse IgG1 kappa-PE isotype control (top) or Mouse anti-Human CD137 (4-1BB)-PE Monoclonal Antibody (bottom). Total viable cells were used for analysis.