Figure 1. The principle of cell isolation using Dynabeads® Biotin Binder (A) and CELLection™ Biotin Binder (A+B). Isolated target cells can only be detached from beads wih CELLection™ Biotin Binder.		One System - no limits! Do you want to: Isolate untouched cells (negative isolation or depletion)? Label the cells with your own biotinylated antibody mix and then add Dynabeads® Biotin Binder to your starting sample to bind unwanted cell types. Use a DynaMagTM magnet to pull the unwanted cells to the tube wall, leaving a high purity and yield of untouched, viable cells in the supernatant. Batch-to-batch variations (fig. 2) and donor variations (fig. 3) are minimal. Isolate bead-free cells (positive isolation with subsequent bead release)? Use CELLection™ Biotin Binder with your own biotinylated antibody (direct or indirect technique) to bind your target cell type. Use a DynaMagTM magnet to pull the target cells to the tube wall, leaving the unwanted cells in the supernatant. After isolation, the beads are detached from the cells by cleaving the DNase linker (reagent supplied). Dynabeads® FlowComp Flexi is another alternative for combining Dynabeads® with your own antibody. This product includes a biotinylation kit and uses a biotin/streptavidin-based release mechanism.