Large Scale Chromatography

When you need high performance and high throughput on a large scale, POROS® Bulk Chromatography Resins are the industry standard for process-scale bioseparations.

Utilized in multiple FDA regulated processes, these breakthrough resins combine optimal particle size and pore structure with a rigid backbone and proprietary chemistries. POROS® 50 µm resins demonstrate exceptionally high dynamic binding capacity, capture efficiency, and resolution over a range of flow rates.

POROS® products are manufactured in a state-of-the-art chromatography resin manufacturing facility and tested using the highest quality standards to support use in regulated biotherapeutic markets.

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Bioproduction Webinar Series

 

Benefits of a Revised Approach to Anion Exchange Flow-Through Polish Chromatography

The new POROS® XS Cation Exchange Resin delivers

  • Dynamic binding capacity for proteins, greater than 100 mg/mL at 5% breakthrough
  • High resolution using optimized 50 μm particle size for improved impurity clearance
  • Robust salt tolerance that maintains dynamic binding capacity to 150 mM NaCl (15 mS/cm)

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POROS® XS

 

 

POROS® XS
 

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  • POROS® XS 50 µm Bulk Resin
    A next-generation strong cation exchange resin that delivers a combination of high capacity, high resolution, and high salt tolerance for greater process flexibility and performance.
  • POROS® HS 50 µm Bulk Resin
    A strong cation exchange resin offering high resolution for the removal of process contaminants and product impurities in downstream polish applications,
  • POROS® MabCapture™ A Resin
    A high performance Protein A chromatography resin technology combining improvements made in bead and chemistry technology to provide high dynamic binding capacities and excellent capture efficiencies at high linear velocities
  • POROS® Heparin 50 µm Bulk Resin
    Heparin affinity media for process scale separation of biomolecules with sepcific Heparin binding affinity, such as growth factors and other serum components, including coagulation factors and nucleotide binding proteins.
  • POROS® R1 50 µm Bulk Resin
    A reversed-Phase Resin for large scale downstream bioprocessing. POROS® R1 is a 4000 angstrom pore size Poly (Styrene-Divinylbenzene) particle, suitable for the reversed-phase separation of biomolecules.
  • POROS® R2 50 µm Bulk Resin
    A reversed-Phase Resin for large scale downstream bioprocessing. POROS® R2 is a 2000 angstrom pore size Poly (Styrene-Divinylbenzene) particle, suitable for the reversed-phase separation of biomolecules.