Downstream Purification for Virus Production

High Performance Resins for Viral Vaccine Production

POROS® resins are uniquely suited for the purification of large biomolecules such as viruses or virus like particles (VLPs). Due to the resin’s large pore size and extensive pore network it is able to provide higher binding capacities for these large molecules while offering excellent resolution and throughput.

Find out more about our POROS® resins.

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Bioproduction Webinar Series

 

Benefits of a Revised Approach
to Anion Exchange Flow-Through
Polish Chromatography

The New POROS® XS Cation Exchange Resin Delivers a Combination of High Capacity + High Resolution + High Salt Tolerance

 

Today’s high titer biotherapeutic processes create a host of downstream purification challenges and bottlenecks. Traditional high-high capacity resins fail to achieve high resolution in purification.  The need for a resin that delivers a combination of high capacity, high resolution, and high salt tolerance can lead to increase process efficiency and help enable a faster time to market for the product.

  • Dynamic binding capacity for proteins, greater than 100 mg/mL at 5% breakthrough
  • High resolution using optimized 50 μm particle size for improved impurity clearance
  • Robust salt tolerance that maintains dynamic binding capacity to 150 mM NaCl (15 mS/cm)

 

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Applied Biosystems® GoPure™ Prepacked Chromatography Columns Offer Convenient, Flexible, and Efficient Purification of Biomolecules

 

Ideal for pilot-scale chromatography unit operations, Applied Biosystems® GoPure™ Prepacked Chromatography Columns from Life Technologies deliver equivalent chromatographic performance and greater convenience at a cost comparable to packing a traditional column.

  • Connect-and-go convenience speeds up process setup and facility turnaround time
  • Prequalified columns simplify process scale-up or modeling
  • Flexible column design can be tailored to process requirements
  • POROS® XS 50 µm Bulk Resin
    A cation exchange resin that delivers the combination of high capacity, high resolution, and high salt tolerance can lead to increased process efficiency and help enable a faster time to market for the product.
  • POROS® HQ 50 µm Bulk Resin
    Strong Anion Echange Resin available for low pressure applications, including large scale downstream bioprocessing. POROS® HQ is based on a quaternized polyethyleneimine functional group yielding a high capacity, Perfusion Chromatography® media designed for the separation and purification of biomolecules.
  • POROS® PI 50 µm Bulk Resin
    Weak Anion Echange Resin for low pressure applications, including large scale downstream bioprocessing. POROS® PI is based on a polyethyleneimine functional group yielding a high capacity, Perfusion Chromatography® media designed for the separation and purification of biomolecules.
  • POROS® Heparin 50 µm Bulk Resin
    Heparin affinity media for process scale separation of biomolecules with sepcific Heparin binding affinity, such as growth factors and other serum components, including coagulation factors and nucleotide binding proteins.

 

  • POROS® R1 50 µm Bulk Resin
    Reversed-Phase Resin for low pressure applications, including large scale downstream bioprocessing. POROS® R1 is a 4000 angstrom pore size Poly (Styrene-Divinylbenzene) particle, suitable for the reversed-phase separation of biomolecules.
  • POROS® R2 50 µm Bulk Resin
    Reversed-Phase Resin for low pressure applications, including large scale downstream bioprocessing. POROS® R2 is a 2000 angstrom pore size Poly (Styrene-Divinylbenzene) particle, suitable for the reversed-phase separation of biomolecules.