Chromatography

When you need high performance and high throughput on a large scale, POROS® Bulk Chromatography Resins used throughout the industry for process-scale bioseparations.

Utilized in multiple FDA- regulated processes, these high-performance resins combine optimal particle size and pore structure with a rigid backbone and proprietary chemistries. POROS® 50 µm resins demonstrate high dynamic binding capacity, capture efficiency, and resolution over a range of flow rates.

High-Performance Resin for Analytical and Lab-Scale Separations

POROS® Analytical Chromatography Columns, available in 10 and 20 micron particle size, enable rapid separation for biomolecules for both analytical and lab-scale preparative applications.

POROS® Protein A Analytical Columns are used throughout the industry
for monitoring monoclonal antibody titer and yield from cell culture supernatant. POROS® Analytical Chromatography columns can be operated on any standard High Performance Liquid Chromatography (HPLC) or medium pressure chromatography system.

Connect-and-Go Convenience for Development and Pilot-Scale Separations

For biopharmaceutical manufacturers in early-phase process development, GoPure™ Pre-packed Chromatography Columns from Life Technologies combine connect-and-go convenience with high-performance POROS® resin.

GoPure™ columns are available in multiple sizes, diameters, and lengths, allowing for easy scalability from bench to larger-scale processing.

High Performance Resins for Microbial Expression Systems

Microbial protein production is an important platform for the production of biotherapeutic proteins. POROS® has many purifcation tools in both analytical and process tools for the large scale purification of this large scale expression system.

High Performance Resins for Viral Vaccine Production

POROS® resins are uniquely suited for the purification of large biomolecules such as viruses or virus like particles (VLPs). Due to the resin’s large pore size and extensive pore network it is able to provide higher binding capacities for these large molecules while offering excellent resolution and throughput.

High Performance Resins for Monoclonal Antibody Production

As cell culture technology improvements continue to result in monoclonal antibody expression level increases, the protein manufacturing throughput bottleneck has shifted to downstream purification. The neck of the funnel exists at the capture chromatography step, where it can days to process a single reactor harvest due to flow rate and capacity limitations of existing rPA affinity medias. Chromatography medias with high dynamic binding capacity and high throughput capability are required to minimize this process bottleneck.