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Gene-Related Products
Rabbit anti-Smad4
Manual / Product Insert
f499d34bd87b42948b3960b8f6b82e74_Manuals
Mouse anti-Smad4
Manual / Product Insert
0ee8b85a85a49346fdff9665312a5cc4_Manuals
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
Citations & References
- Authors: Bornstein, S; White, R; Malkoski, S; Oka, M; Han, GW; Cleaver, T; Reh, D; Andersen, P; Gross, N; Olson, S; Deng, CX; Lu, SL; Wang, XJ
- Journal: JOURNAL OF CLINICAL INVESTIGATION 2009 11:3408-3419
- Product Usage: TaqMan® Gene Expression Assays;TaqMan® Master Mixes;TaqMan® RT-PCR (One-Step & Two-Step) Kits & Reagents
- ID: PN110631
aebf825f224710bf5838e6826297ea57_Citations
SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway.
Citations & References
- Authors: Woodford-Richens K L; Rowan A J; Gorman P; Halford S; Bicknell D C; Wasan H S; Roylance R R; Bodmer W F; Tomlinson I P;
- Journal: Proc Natl Acad Sci U S A (2001) 98:9719-9742
- Product Usage: RNA was extracted from a subset of CRC cell lines (SW1222, HRA19, SKC01, SW948, JW, HCT8, COLO205, LS174T, SW48, LOVO, SW620, COLO320, GP2D, HT29, CACO2, and HCA46) by using the Fast-track RNA extraction kit.
- ID: PN65251
- Catalog #s
- K159302
50ac4b2d6257c591a057a922533f77d5_Citations
Smad4-dependent TGF-β signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells
Citations & References
- Authors: Zhao, S; Ammanamanchi, S; Brattain, M; Cao, L; Thangasamy, A; Wang, J; Freeman, JW
- Journal: JOURNAL OF BIOLOGICAL CHEMISTRY 2008 17:11293-11301
- Product Usage: SYBR® Green Reagents
- ID: PN78928
1c7963844aaa8741078058405db5d5eb_Citations
Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity.
Citations & References
- Authors: Owens P, Bazzi H, Engelking E, Han G, Christiano AM, Wang XJ
- Journal: Dev Biol 2008 1:156-166
- Product Usage: TaqMan® Gene Expression Assays
- ID: PN126113
7961a0fb94e5089213f0f2b05f8ce677_Citations
Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.
Citations & References
- Authors: Müller N, Reinacher-Schick A, Baldus S, van Hengel J, Berx G, Baar A, van Roy F, Schmiegel W, Schwarte-Waldhoff I,
- Journal: Oncogene (2002) 21:6049-6058
- Product Usage: Immunofluorescence staining and Western blotting of SW480 and MDA-MB-231 cells
- ID: PN132758
- Catalog #s
- 135800
3c3039ee651de4bb59c1d1066cee3f6b_Citations
Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer
Citations & References
- Authors: Aitchison, AA; Veerakumarasivam, A; Vias, M; Kumar, R; Hamdy, FC; Neal, DE; Milis, IG
- Journal: PROSTATE 2008 6:661-674
- Product Usage: Capillary Electrophoresis Systems
- ID: PN79202
35d5c6b689a4bd2db8843f661814fb4b_Citations
Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis
Citations & References
- Authors: Van Hattem, WA; Brosens, LAA; de Leng, WWJ; Morsink, FH; Lens, S; Carvalho, R; Giardiello, FM; Offerhaus, GJA
- Journal: GUT 2008 5:623-627
- Product Usage: Capillary Electrophoresis Systems
- ID: PN78666
89cb11cbb1febbdbe6d6af571b3f3125_Citations
Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts
Citations & References
- Authors: Shimada, K; Ikeda, K; Ito, K
- Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009 3:775-779
- Product Usage: TaqMan® Master Mixes
- ID: PN112473
0012b2aed5203803fec32ea4297c20ca_Citations
The up-regulation of 14-3-3 proteins in Smad4 deficient epidermis and hair follicles at catagen
Citations & References
- Authors: Yuan, C; Jiao, L; Yang, L; Ying, W; Hu, ZS; Liu, JF; Cui, F; Li, L; Qian, LY; Teng, Y; Hang, HY; Qian, XH; Yang, X
- Journal: PROTEOMICS 2008 11:2230-2243
- Product Usage: 4800 MALDI TOF/TOF Analyzer
- ID: PN81867
67b41e97520341818e0df2b19384fc6f_Citations
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.
Citations & References
- Authors: Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S,
- Journal: Cell (2009) 136:123-135
- Product Usage: HaCaT, HCT116chr3, HEK293T, and HeLa cells
- ID: PN68861
abb78f41c0c8e19bb91a4295615eae62_Citations
4E-BP1 is a target of Smad4 essential for TGFβ-mediated inhibition of cell proliferation
Citations & References
- Authors: Azar, R; Alard, A; Susini, C; Bousquet, C; Pyronnet, S
- Journal: EMBO JOURNAL 2009 22:3514-3522
- Product Usage: siPORT™ Transfection Agents
- ID: PN111303
5091a0aa85e5a1bf1120fd6183e77bf9_Citations
Smad4/DPC4-dependent Regulation of Biglycan Gene Expression by Transforming Growth Factor-beta in Pancreatic Tumor Cells.
Citations & References
- Authors: Chen Wen-Bin; Lenschow Wolfgang; Tiede Karen; Fischer Jens W; Kalthoff Holger; Ungefroren Hendrik;
- Journal: J Biol Chem (2002) 277:36118-36146
- Product Usage: PANC-1 cells were transfected with luciferase constructs using LipofectAMINE Plus. For retroviral transduction, the full-length and a C-terminally truncated mutant of Smad4/DPC4 were cloned into retroviral vector and were cotransfected into 293T producer cells with retroviral packaging vectors. Retroviral particles released by 293T cells were used to infect PANC-1, and CFPAC-1 cells. Infected cells were obtained by selection with Geneticin (PANC-1, 700 µg/ml; CFPAC-1, 350 µg/ml).
- ID: PN63049
8e1f647f0d7d91df0cf3c7d10b37a236_Citations
