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RAF1 Kinase Inhibitor I
| Catalog # | Unit Size | List Price | Contact Us |
|---|---|---|---|
| PHZ1263 | 1 mg |
Description
Raf1 Kinase Inhibitor I is a potent inhibitor of c-Raf1. This compound has been assessed with a number of other enzymes, including Cdk1, Cdk2, c-Src, ERK2, MEK, p38 MAPK, Tie2, View full product details >
General Specifications
- Form
-
Solid
- Sterility
-
Non-sterile
- Product Size
-
1 mg
- Purification
-
HPLC
- Inhibitor Type
-
Kinase Inhibitor
Kinase Inhibitor (MAP Kinase Inhibitor)
- Molecular Weight
-
520.9 Da
- Inhibitor Properties
-
Chemical
- Specific Inhibitor Target
-
c-RAF 1
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Cell Culture
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
Rate this productRAF1 (cRAF) [Y340D] [Y341D] Recombinant Human Protein
See all Serine⁄Threonine Kinases
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4046 | 1 mg | 5400.00 |
Description
RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can View full product details >
General Specifications
- Form
-
Frozen
- Species
-
Human
- Gene Aliases
-
RAF1 (cRAF) Y340D Y341D
- Kinase Group
-
Ser⁄Thr Kinases: TKL Group
- Product Size
-
1 mg
- Accession Number
-
NP_002871, Y340D, Y341D
- Molecular Weight
-
66.4 kDa
- Research Category
-
Drug Development
- Validated Application
-
Kinase Assay
- Protein Tag or Fusion
-
GST Tag
- Expression
-
Baculovirus
- Kinase Family
-
RAF Kinase Family
- Protein Form
-
Catalytic
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Proteins, Expression, Isolation & Analysis
User Ratings
RAF1 (cRAF) [Y340D] [Y341D] Recombinant Human Protein
See all Serine⁄Threonine Kinases
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PR7307A | 100 µg | 1250.00 |
Description
RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can View full product details >
General Specifications
- Form
-
Frozen
- Species
-
Human
- Gene Aliases
-
RAF1 (cRAF) Y340D Y341D
- Kinase Group
-
Ser⁄Thr Kinases: TKL Group
- Product Size
-
100 µg
- Accession Number
-
NP_002871, Y340D, Y341D
- Molecular Weight
-
66.4 kDa
- Research Category
-
Drug Development
- Validated Application
-
Kinase Assay
- Protein Tag or Fusion
-
GST Tag
- Expression
-
Baculovirus
- Kinase Family
-
RAF Kinase Family
- Protein Form
-
Catalytic
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Proteins, Expression, Isolation & Analysis
User Ratings
RAF1 (cRAF) [Y340D] [Y341D] Recombinant Human Protein
See all Serine⁄Threonine Kinases
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV3805 | 10 µg | 376.00 |
Description
RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can View full product details >
General Specifications
- Gene ID
-
4773, 5894
- Species
-
Human
- Target Gene
-
v-raf-1 murine leukemia viral oncogene homolog 1
- Gene Aliases
-
RAF1 (cRAF) Y340D Y341D
- Kinase Group
-
Ser⁄Thr Kinases: TKL Group
- Product Size
-
10 µg
- Protein Family
-
Kinases & Inhibitors
- Protein Subtype
-
Serine⁄Threonine Kinases
- Accession Number
-
NP_002871, Y340D, Y341D
- Molecular Weight
-
66.4 kDa
- Research Category
-
Signal Transduction
- System Compatibility
-
Z'-LYTE™
Omnia® Bulk Substrate
LanthaScreen™ Substrate
LanthaScreen™ Antibody
- Validated Application
-
Kinase Assay
- Protein Length or Portion (a.a.)
-
aa 306-648; Y340D, Y341D
- Protein Tag or Fusion
-
GST Tag
- Expression
-
Baculovirus
- Kinase Family
-
RAF Kinase Family
- Protein Form
-
Recombinant
Catalytic
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
LanthaScreen® Tb-pMAP2K1 (pSer217⁄221) Antibody Kit
See all TR-FRET Primary Antibodies
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4813 | 25 µg | 3049.00 |
Description
A member of the MAP Kinase family, MAP2K1 (mitogen-activated protein kinase kinase 1) is phosphorylated at Ser217/221 by a range of MAPK family members including Raf and B-Raf. For View full product details >
General Specifications
- Format
-
384-well plate
- Gene ID
-
10454, 10746, 1326, 4215, 4217, 4293, 4294, 4296, 5894, 673, 6885
- Readout
-
End Point
- Technique
-
TR-FRET
- Reactivity
-
Human
- Label or Dye
-
FITC (Fluorescein)
Terbium (Tb)
- Product Size
-
25 µg
- Target Enzyme
-
Serine⁄Threonine Kinases
- Validated Kinases
-
BRAF, MAP3K2, MAP3K3, MAP3K5, MAP3K7, MAP3K8, MAP3K9, MAP3K10, MAP3K11
- Antibody Molecular Weight
-
150000 Da
- Excitation⁄Emission (nm)
-
340⁄490, 520
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
LanthaScreen® Tb-pMAP2K1 (pSer217⁄221) Antibody Kit
See all TR-FRET Primary Antibodies
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4814 | 1 mg | 17050.00 |
Description
A member of the MAP Kinase family, MAP2K1 (mitogen-activated protein kinase kinase 1) is phosphorylated at Ser217/221 by a range of MAPK family members including Raf and B-Raf.
View full product details >
General Specifications
- Format
-
384-well plate
- Gene ID
-
10454, 10746, 1326, 4215, 4217, 4293, 4294, 4296, 5894, 673, 6885
- Readout
-
End Point
- Technique
-
TR-FRET
- Reactivity
-
Human
- Label or Dye
-
FITC (Fluorescein)
Terbium (Tb)
- Product Size
-
1 mg
- Target Enzyme
-
Serine⁄Threonine Kinases
- Validated Kinases
-
BRAF, MAP3K2, MAP3K3, MAP3K5, MAP3K7, MAP3K8, MAP3K9, MAP3K10, MAP3K11
- Antibody Molecular Weight
-
150000 Da
- Excitation⁄Emission (nm)
-
340⁄490, 520
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
Fluorescein-MAP2K1
See all Kinase & Phosphatase Substrates
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4812 | 20 nmols | 661.00 |
Description
Inactive MAP2K1 (MEK1) has been labeled with fluorescein, and is a substrate for MAPK family members.
For use in combination with the LanthaSreen™ Tb-MAP2K1 [pSer217/
View full product details >
General Specifications
- Gene ID
-
10454, 10746, 1326, 4215, 4217, 4293, 4294, 4296, 5894, 673, 6885
- Substrate
-
MAP2K1
- Label or Dye
-
FITC (Fluorescein)
- Product Size
-
20 nmols
- Target Enzyme
-
Serine⁄Threonine Kinases
- Substrate Type
-
Kinase Substrate
- Detection Method
-
Fluorescent
- Molecular Weight
-
50000 Da
- Validated Kinases
-
BRAF, MAP3K2, MAP3K3, MAP3K5, MAP3K7, MAP3K8, MAP3K9, MAP3K10, MAP3K11
- Substrate Properties
-
Protein-Based Substrate
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
c-Raf [pS621] Rabbit Polyclonal Antibody View 1 Citations
See all Protein Specific Primary Antibodies
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| 44504G | 10 blots | 299.00 |
Description
c-RAF [pS621] PAb hu, (ms, rt) ; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pS621]. This antibody is validated for use in Western Blot. Anti-c-Raf [ View full product details >
General Specifications
- Reactivity
-
Human
- Validated Application
-
Western Blot
- Host
-
Rabbit
- Clonality
-
Polyclonal
- Target Gene
-
c-RAF [pS621]
- Gene ID
-
5894
- Label or Dye
-
Unconjugated
- Target Modification State
-
Phospho
- Purification
-
Purified
- Product Size
-
10 blots
- Shipping Condition
-
Approved for shipment on Wet or Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
BRAF [V599E] Recombinant Human Protein
See all Serine⁄Threonine Kinases
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV3849 | 10 µg | 376.00 |
Description
BRAF acts upstream of MEK in the MAP kinase pathway and is involved in cell division, differentiation, and secretion. The BRAF mutant V599E is oncogenic and found in a variety of View full product details >
General Specifications
- Mass
-
10 µg
- Gene ID
-
10488, 673
- Species
-
Human
- Target Gene
-
v-raf murine sarcoma viral oncogene homolog B1
- Gene Aliases
-
BRAF V599E
- Kinase Group
-
Ser⁄Thr Kinases: TKL Group
- Product Size
-
10 µg
- Protein Family
-
Kinases & Inhibitors
- Protein Subtype
-
Serine⁄Threonine Kinases
- Accession Number
-
NP_004324.1, V599E
- Molecular Weight
-
67.1 kDa
- Research Category
-
Oncology
Signal Transduction
- System Compatibility
-
Z'-LYTE™
LanthaScreen™ Substrate
LanthaScreen™ Antibody
- Validated Application
-
Kinase Assay
- Protein Length or Portion (a.a.)
-
aa 416-766
- Protein Tag or Fusion
-
GST Tag
- Tag Position
-
N-Terminal
- Expression
-
Baculovirus
- Kinase Family
-
RAF Kinase Family
- Protein Form
-
Recombinant
Catalytic
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
Z′-LYTE® Kinase Assay Kit - Ser/Thr 3 Peptide
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV3176 | 800 × 20 µl assays | 522.00 |
Description
A coumarin and fluorescein-labeled peptide substrate which can be used for kinase screening in an antibody-free format. This peptide is based upon bovine MBP Thr-97 derived View full product details >
General Specifications
- Format
-
384-well plate
- Readout
-
End Point
- Technique
-
FRET
- Assay Type
-
Serine⁄Threonine Kinase Assay
- References
-
BBRC vol. 61, pp 559-563 (1974), JBC, vol 252, p 4888 (1978)
- Label or Dye
-
Coumarin
- Product Size
-
800 × 20 µl assays
- Target Enzyme
-
Serine⁄Threonine Kinases
- Validated Kinases
-
BRAF, MAPK1, MAPK3, MAPK12, MAPK13, MAP2K1, MAP2K2, MAP3K6, MAP2K8
- Number of Reactions
-
800 Reactions
- Substrate Properties
-
Peptide-Based Substrate
- Protein or Peptide Source
-
Bovine MBP, Thr-97 derived peptide S5
Consensus seq Pro-X-(Ser⁄Thr)-Pro (APRTPGGRR)
- Excitation⁄Emission (nm)
-
405⁄465, 535
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
BRAF Recombinant Human Protein
See all Serine⁄Threonine Kinases
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4172 | 1 mg | 5400.00 |
Description
BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play View full product details >
General Specifications
- Form
-
Frozen
- Species
-
Human
- Gene Aliases
-
BRAF, BRAF1
- Kinase Group
-
Ser⁄Thr Kinases: TKL Group
- Product Size
-
1 mg
- Accession Number
-
NP_004324.2
- Molecular Weight
-
113.6 kDa
- Research Category
-
Drug Development
- Validated Application
-
Kinase Assay
- Protein Tag or Fusion
-
GST Tag
- Expression
-
Baculovirus
- Kinase Family
-
RAF Kinase Family
- Protein Form
-
Full Length
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Proteins, Expression, Isolation & Analysis
User Ratings
c-Raf [pS259] Rabbit Polyclonal Antibody
See all Protein Specific Primary Antibodies
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| 44502 | 10 blots | 299.00 |
Description
c-RAF [pS259] PAb; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pS259]. This antibody is validated for use in Western Blot. Anti-c-Raf [pS259] recognizes View full product details >
General Specifications
- Reactivity
-
Human
- Validated Application
-
Western Blot
- Host
-
Rabbit
- Clonality
-
Polyclonal
- Target Gene
-
c-Raf [pS259]
- Gene ID
-
5894
- Label or Dye
-
Unconjugated
- Target Modification State
-
Phospho
- Product Size
-
10 blots
- Purity or Quality Grade
-
Azide Free
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Cell Analysis
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
c-Raf [pYpY340/341] Rabbit Polyclonal Antibody View 2 Citations
See all Protein Specific Primary Antibodies
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| 44506G | 10 blots | 299.00 |
Description
c-RAF [pYpY340⁄341] PAb; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pY340⁄pY341]. This antibody is validated for use in Western Blot, View full product details >
General Specifications
- Reactivity
-
Rat
Human
Mouse
- Validated Application
-
Immunohistochemistry
Western Blot
- Host
-
Rabbit
- Clonality
-
Polyclonal
- Target Gene
-
c-Raf [pYpY340/341]
- Gene ID
-
5894
- Label or Dye
-
Unconjugated
- Target Modification State
-
Phospho
- Product Size
-
10 blots
- Purity or Quality Grade
-
Azide Free
- Shipping Condition
-
Approved for shipment on Wet or Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Cell Analysis
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
BRAF Recombinant Human Protein
See all Serine⁄Threonine Kinases
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV3848 | 10 µg | 376.00 |
Description
BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play View full product details >
General Specifications
- Gene ID
-
2353, 673
- Species
-
Human
- Target Gene
-
v-raf murine sarcoma viral oncogene homolog B1
- Gene Aliases
-
BRAF, BRAF1
- Kinase Group
-
Ser⁄Thr Kinases: TKL Group
- Product Size
-
10 µg
- Protein Family
-
Kinases & Inhibitors
- Protein Subtype
-
Serine⁄Threonine Kinases
- Accession Number
-
NP_004324.2
- Molecular Weight
-
113.6 kDa
- Research Category
-
Oncology
Signal Transduction
- System Compatibility
-
Z'-LYTE™
Omnia® Bulk Substrate
LanthaScreen™ Substrate
LanthaScreen™ Antibody
- Validated Application
-
Kinase Assay
- Protein Tag or Fusion
-
GST Tag
- Expression
-
Baculovirus
- Kinase Family
-
RAF Kinase Family
- Protein Form
-
Recombinant
Full Length
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
