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Taqman® Mutation Detection Assays
The TaqMan® Mutation Detection Assays, powered by the castPCR™ technology, provide a highly specific and sensitive method to detect mutations in gene that are associated with cancer.
PIK3CA⁄PIK3R1 (p110 alpha⁄p85 alpha) Recombinant Human Protein
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4788 | 20 µg | 455.00 |
Description
PIK3CA (p110 alpha) is known to be involved in the PI 3-kinase⁄AKT signaling pathway, which plays an important role in regulating cell growth and apoptosis. PIK3CA is View full product details >
General Specifications
- Gene ID
-
5290
- Species
-
Human
- Expression
-
Baculovirus
- Target Gene
-
phosphoinositide-3-kinase, catalytic, alpha polypeptide
- Gene Aliases
-
PIK3CA/PIK3R1 (p110 alpha/p85 alpha), PI3 Kinase alpha
- Kinase Group
-
Lipid Kinases
- Product Size
-
20 µg
- Tag Position
-
His (N-Terminal)⁄None
- Protein Family
-
Kinases & Inhibitors
- Protein Subtype
-
Lipid Kinases
- Accession Number
-
NP_003209.2 ⁄ NP_852664.1
- Molecular Weight
-
128.4⁄83.6 kDa
- Research Category
-
Signal Transduction
- System Compatibility
-
Adapta™
- Protein Tag or Fusion
-
His Tag
- Validated Application
-
Kinase Assay
- Kinase Family
-
PI3 Kinase
- Protein Form
-
Full Length
Recombinant
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
Rate this productPIK3CA⁄PIK3R1 (p110 alpha⁄p85 alpha) Recombinant Human Protein
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4789 | 1 mg | 5400.00 |
Description
PIK3CA (p110 alpha) is known to be involved in the PI 3-kinase⁄AKT signaling pathway, which plays an important role in regulating cell growth and apoptosis. PIK3CA is View full product details >
General Specifications
- Form
-
Frozen
- Species
-
Human
- Expression
-
Baculovirus
- Gene Aliases
-
PIK3CA/PIK3R1 (p110 alpha/p85 alpha), PI3 Kinase alpha
- Kinase Group
-
Lipid Kinases
- Product Size
-
1 mg
- Accession Number
-
NP_003209.2 ⁄ NP_852664.1
- Molecular Weight
-
212 kDa
- Research Category
-
Drug Development
- Protein Tag or Fusion
-
His Tag
- Validated Application
-
Kinase Assay
- Kinase Family
-
PI3 Kinase
- Protein Form
-
Full Length
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Proteins, Expression, Isolation & Analysis
User Ratings
PIK3CA⁄PIK3R1 (p110 alpha⁄p85 alpha) Recombinant Human Protein
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PR8581C | 100 µg | 1250.00 |
Description
PIK3CA (p110 alpha) is known to be involved in the PI 3-kinase⁄AKT signaling pathway, which plays an important role in regulating cell growth and apoptosis. PIK3CA is View full product details >
General Specifications
- Form
-
Frozen
- Species
-
Human
- Expression
-
Baculovirus
- Gene Aliases
-
PIK3CA/PIK3R1 (p110 alpha/p85 alpha), PI3 Kinase alpha
- Kinase Group
-
Lipid Kinases
- Product Size
-
100 µg
- Accession Number
-
NP_003209.2 ⁄ NP_852664.1
- Molecular Weight
-
212 kDa
- Research Category
-
Drug Development
- Protein Tag or Fusion
-
His Tag
- Validated Application
-
Kinase Assay
- Kinase Family
-
PI3 Kinase
- Protein Form
-
Full Length
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Proteins, Expression, Isolation & Analysis
User Ratings
CellSensor® T-REx™ FOXO3 DBE-bla HeLa Cell Line
See all Pathway Analysis Cell Based Assay Kits
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| K1468 | 1 vial | 9949.00 |
Description
The CellSensor® T-REx™ FOXO3 DBE-bla HeLa cell line was engineered by lentiviral transduction of HeLa cervical cancer cells with a FOXO3 response element driving View full product details >
General Specifications
- System
-
CellSensor™
- Cell Line
-
HeLa
- Cell State
-
Dividing Cells
- Product Size
-
1 vial
- Detection Method
-
Fluorescent
- Druggable Target
-
Kinases
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Cell Analysis
- Drug Discovery & Development
User Ratings
Adapta™ Universal Kinase Assay Kit
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV5099 | 1 kit | 656.00 |
Description
The Adapta™ Universal Kinase Assay Kit is a homogenous, fluorescence-based immunoassay for the detection of ADP produced by kinases or other ATP dependent enzymes.
For
View full product details >
General Specifications
- Format
-
384-well plate
- Gene ID
-
1022, 1147, 120892, 1612, 3376, 5289, 5290, 5294, 8536
- Readout
-
End Point
- Technique
-
TR-FRET
- Assay Type
-
Universal Kinase Assay
- Label or Dye
-
Europium
Alexa Fluor® 647
- Product Size
-
1 kit
- Target Enzyme
-
Kinases (Multiple)
- Validated Kinases
-
CAMK1, CDK7, CDK9, CHUK, LRRK2, PI4KB, PIK3C2B, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3C2A
- Excitation⁄Emission (nm)
-
340⁄615, 665
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
Kinase Tracer 1710, 25 µM
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV6088 | 25 µl | 361.00 |
Description
In the LanthaScreen® Eu Kinase Binding Assay, binding of an Alexa Fluor® conjugate or “tracer" such as Kinase Tracer 1710 to a kinase is detected by addition of View full product details >
General Specifications
- Format
-
384-well plate
- Readout
-
Kinetic
- Platform
-
Microplate Reader
- Technique
-
TR-FRET
- Assay Type
-
Kinase Binding Assay
- Label or Dye
-
Alexa Fluor® 647
- Product Size
-
25 µl
- Target Enzyme
-
Kinases (Multiple)
- cGMP Compliance
-
non-cGMP Compliant
- Validated Kinases
-
PIK3CA, ABL1, ABL1 E255K, ABL1 G250E, ABL1 Y253F, WNK3
- Excitation⁄Emission (nm)
-
340⁄615, 665
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
User Ratings
PIP2:PS Lipid Kinase Substrate
See all Kinase & Phosphatase Substrates
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV5100 | 400 nmol | 648.00 |
Description
Specifically optimized for use with the Class I PI3 kinases (PIK3CA, PIK3CB, PIK3CD, and PIK3CG), this substrate consists of lipid vesicles of a 1:19 molar ratio of phosphoinositol View full product details >
General Specifications
- Gene ID
-
5290, 5294
- Substrate
-
Phosphoinositol-4,5-bisphosphate (PIP2) lipid vesicles with phosphoserine (PS)
- Product Size
-
400 nmol
- Target Enzyme
-
Lipid Kinases
- Substrate Type
-
Kinase Substrate
- Detection Method
-
Fluorescent
- Validated Kinases
-
PIK3CA, PIK3CG, PIK3CB, PIK3CD
- Substrate Properties
-
Lipid-Based Substrate
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
WORTMANNIN
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PHZ1301 | 1 mg | 103.00 |
Description
Wortmannin, a fungal metabolite, is a potent and selective inhibitor of phosphatidylinositol 3-kinase.
Format/Formulation: Lyophilized
View full product details >
General Specifications
- Form
-
Solid
- Gene ID
-
5290, 5291, 5293, 5294
- Sterility
-
Non-sterile
- Product Size
-
1 mg
- Purification
-
TLC
- Inhibitor Type
-
Kinase Inhibitor (PI 3-Kinase Inhibitor)
Kinase Inhibitor
- Molecular Weight
-
428.4 Da
- Inhibitor Properties
-
Chemical
- Specific Inhibitor Target
-
PI3-Kinase
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Cell Culture
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
PIK3CA (PIK3R1) LanthaScreen Binding Assay Validation Packet
Manual / Product Insert
PIK3CA/PIK3R1 Adapta Assay Validation Packet
Manual / Product Insert
PIK3CA⁄PIK3R1 (p110 alpha⁄p85 alpha) Recombinant Human Protein
MSDS
PIK3CA⁄PIK3R1 (p110 alpha⁄p85 alpha) Recombinant Human Protein
MSDS
PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences
Citations & References
- Authors: Miyake, T; Yoshino, K; Enomoto, T; Takata, T; Ugaki, H; Kim, A; Fujiwara, K; Miyatake, T; Fujita, M; Kimura, T
- Journal: CANCER LETTERS 2008 1:120-126
- Product Usage: SYBR® Green Reagents
- ID: PN77348
