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LanthaScreen® Tb-anti-PDCD4 [pSer457] Antibody Kit View 1 Citations
See all TR-FRET Primary Antibodies
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV5105 | 1 mg | 14396.63 |
Description
A part of the PI3K/AKT Pathway, PDCD4 (programmed cell death protein 4) is phosphorylated at Ser457 indirectly via mTORC1 (through the ribosomal protein p70 S6 kinase).
For
View full product details >
General Specifications
- Reactivity
-
Human
- Label or Dye
-
Terbium (Tb)
- Product Size
-
1 mg
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
User Ratings
Rate this productLanthaScreen® Tb-anti-PDCD4 [pSer457] Antibody Kit View 1 Citations
See all TR-FRET Primary Antibodies
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV5104 | 25 µg | 2842.00 |
Description
A part of the PI3K/AKT Pathway, PDCD4 (programmed cell death protein 4) is phosphorylated at Ser457 indirectly via mTORC1 (through the ribosomal protein p70 S6 kinase).
For
View full product details >
General Specifications
- Reactivity
-
Human
- Label or Dye
-
Terbium (Tb)
- Product Size
-
25 µg
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
User Ratings
LanthaScreen™ PDCD4 HEK293E Cell Line View 1 Citations
See all Pathway Analysis Cell Based Assay Kits
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| K1593 | 1 vial | 9949.00 |
Description
The PI3K⁄AKT⁄mTOR pathway mediates signals for cell growth and survival, transcription and translation, and regulated cell death. The significance of mTOR has been View full product details >
General Specifications
- System
-
LanthaScreen®
- Readout
-
End Point
- Reporter
-
GFP (EmGFP)
- Cell State
-
Dividing Cells
- Antagonists
-
PMA
IGF-1
- Gene Symbol
-
PDCD4
- Product Size
-
1 vial
- Primary Agonist
-
Insulin
- Druggable Target
-
Signaling Pathway
Kinases
- Alternate Agonists
-
Insulin
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
User Ratings
LanthaScreen PDCD4 HEK293E Cell-based Assay
Manual / Product Insert
LanthaScreen™ PDCD4 HEK293E S457 Validation Packet
Manual / Product Insert
LanthaScreen™ PDCD4 HEK293E Cell Line
MSDS
LanthaScreen® Tb-anti-PDCD4 [pSer457] Antibody Kit
MSDS
LanthaScreen® Tb-anti-PDCD4 [pSer457] Antibody Kit
MSDS
Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors.
Citations & References
- Authors: Leupold JH; Yang HS; Colburn NH; Asangani I; Post S; Allgayer H
- Journal: Oncogene 2007 13:4550-4562
- Product Usage: TaqMan® Gene Expression Assays
- ID: PN71021
Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer
Citations & References
- Authors: Wei, N; Liu, SS; Leung, THY; Tam, KF; Liao, XY; Cheung, ANY; Chan, KKL; Ngan, HYS
- Journal:
- Product Usage: SYBR® Green Reagents
- ID: PN107883
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.
Citations & References
- Authors: Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH,
- Journal: Mol Cell Biol (2006) 26:1297-1306
- Product Usage: Briefly, pLenti-Pdcd4 and pLenti-control (pLenti6/V5-DEST with the ccdB gene deleted) were cotransfected with the mixture of the packaging plasmids (Invitrogen) into 293 FT cells. After 72 h, the viral supernatant was collected by centrifugation at 3,000 rpm for 15 min. The viral titer was determined by transduction of RKO cells with serial dilutions of the viral supernatant and colony counting after blasticidin selection (8 µg/ml).
- ID: PN62739
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.
Citations & References
- Authors: Zakowicz H, Yang HS, Stark C, Wlodawer A, Laronde-Leblanc N, Colburn NH,
- Journal: RNA (2005) 11:261-274
- Product Usage: The Eukaryotic Initiation Factor (eIF) was clone in pcDNA4/HisMaX for expression and subsequent detection and immunoprecipitation. The GeneTailor system was used to introduce point mutations in the eIF4A gene. Vectors for mammalian two-hydrid screening were transfected into RT101 cell using Lipofectamine. The authors also used Sf9 cells for their work and cultured them in SF-900 II SFM medium.
- ID: PN63006
Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherap
Citations & References
- Authors: Bourguignon LY, Spevak CC, Wong G, Xia W, Gilad E
- Journal: J Biol Chem 2009 39:26533-26546
- Product Usage: siPORT™ Transfection Agents
- ID: PN122176
Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.
Citations & References
- Authors: Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH
- Journal: J Biol Chem 2008 2:1026-1033
- Product Usage:
- ID: PN121071
