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PAK4 Recombinant Human Protein
See all Serine⁄Threonine Kinases
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4284 | 1 mg | 5400.00 |
Description
PAK4 is a serine⁄ threonine p21 activating kinase implicated in the reorganization of actin cytoskeleton and in the formation of filopodia. View full product details >
General Specifications
- Form
-
Frozen
- Species
-
Human
- Gene Aliases
-
PAK4
- Kinase Group
-
Ser⁄Thr Kinases: STE Group
- Product Size
-
1 mg
- Accession Number
-
NP_005875
- Molecular Weight
-
61.6 kDa
- Research Category
-
Drug Development
- Validated Application
-
Kinase Assay
- Protein Tag or Fusion
-
GST Tag
- Expression
-
Baculovirus
- Kinase Family
-
STE20 Kinase Family
- Protein Form
-
Catalytic
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Proteins, Expression, Isolation & Analysis
User Ratings
Rate this productPAK4 Recombinant Human Protein
See all Serine⁄Threonine Kinases
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4212 | 10 µg | 376.00 |
Description
PAK4 is a serine⁄ threonine p21 activating kinase implicated in the reorganization of actin cytoskeleton and in the formation of filopodia. View full product details >
General Specifications
- Gene ID
-
10298, 3454
- Species
-
Human
- Target Gene
-
p21 protein (Cdc42⁄Rac)-activated kinase 4
- Gene Aliases
-
PAK4
- Kinase Group
-
Ser⁄Thr Kinases: STE Group
- Product Size
-
10 µg
- Protein Family
-
Kinases & Inhibitors
- Protein Subtype
-
Serine⁄Threonine Kinases
- Accession Number
-
NP_005875
- Molecular Weight
-
91.5 kDa
- Research Category
-
Signal Transduction
- System Compatibility
-
Z'-LYTE™
Omnia® Bulk Substrate
LanthaScreen™ Substrate
LanthaScreen™ Antibody
- Validated Application
-
Kinase Assay
- Protein Length or Portion (a.a.)
-
aa 295-591
- Protein Tag or Fusion
-
GST Tag
- Expression
-
Baculovirus
- Kinase Family
-
STE20 Kinase Family
- Protein Form
-
Recombinant
Catalytic
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
PAK4 Recombinant Human Protein
See all Serine⁄Threonine Kinases
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PR7856A | 100 µg | 1250.00 |
Description
PAK4 is a serine⁄ threonine p21 activating kinase implicated in the reorganization of actin cytoskeleton and in the formation of filopodia. View full product details >
General Specifications
- Form
-
Frozen
- Species
-
Human
- Gene Aliases
-
PAK4
- Kinase Group
-
Ser⁄Thr Kinases: STE Group
- Product Size
-
100 µg
- Accession Number
-
NP_005875
- Molecular Weight
-
61.6 kDa
- Research Category
-
Drug Development
- Validated Application
-
Kinase Assay
- Protein Tag or Fusion
-
GST Tag
- Expression
-
Baculovirus
- Kinase Family
-
STE20 Kinase Family
- Protein Form
-
Catalytic
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Proteins, Expression, Isolation & Analysis
User Ratings
LanthaScreen® Tb-pCrosstide Antibody Kit
See all TR-FRET Primary Antibodies
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV3564 | 25 µg | 3458.00 |
Description
A general assay for serine/threonine kinases, the sequence of the Crosstide substrate is based upon GSK-3alpha/beta. The antibody is directed towards the phosphorylated Crosstide View full product details >
General Specifications
- Format
-
384-well plate
- Gene ID
-
10000, 10298, 207, 208, 25400, 51347, 5566, 56164, 57144, 6197, 6198, 8536
- Readout
-
End Point
- Technique
-
TR-FRET
- Reactivity
-
Human
- Label or Dye
-
FITC (Fluorescein)
Terbium (Tb)
- Product Size
-
25 µg
- Target Enzyme
-
Serine⁄Threonine Kinases
- Validated Kinases
-
AKT1, AKT2, AKT3, CAMK2A, CAMK2D, PAK1, PAK4, PAK7, PRKACA, RPS6KB1, RPS6KA3, TAOK3
- Antibody Molecular Weight
-
150000 Da
- Excitation⁄Emission (nm)
-
340⁄490, 520
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Cell Analysis
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
LanthaScreen® Tb-pCrosstide Antibody Kit
See all TR-FRET Primary Antibodies
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV3565 | 1 mg | 17620.00 |
Description
A general assay for serine/threonine kinases, the sequence of the Crosstide substrate is based upon GSK-3alpha/beta. The antibody is directed towards the phosphorylated Crosstide View full product details >
General Specifications
- Format
-
384-well plate
- Gene ID
-
10000, 10298, 207, 208, 25400, 51347, 56164, 57144, 6197, 6198, 8536
- Readout
-
End Point
- Technique
-
TR-FRET
- Reactivity
-
Human
- Label or Dye
-
FITC (Fluorescein)
Terbium (Tb)
- Product Size
-
1 mg
- Target Enzyme
-
Serine⁄Threonine Kinases
- Validated Kinases
-
AKT1, AKT2, AKT3, CAMK2A, CAMK2D, PAK1, PAK4, PAK7, PRKACA, RPS6KB1, RPS6KA3, TAOK3
- Antibody Molecular Weight
-
150000 Da
- Excitation⁄Emission (nm)
-
340⁄490, 520
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Cell Analysis
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
Z′-LYTE® Kinase Assay Kit - Ser/Thr 20 Peptide
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV4532 | 800 × 20 µl assays | 522.00 |
Description
A coumarin and fluorescein-labeled peptide substrate which can be used for kinase screening in an antibody-free format. This peptide is based upon a synthetic peptide substrate View full product details >
General Specifications
- Format
-
384-well plate
- Readout
-
End Point
- Technique
-
FRET
- Assay Type
-
Serine⁄Threonine Kinase Assay
- References
-
EMBO J. vol. 17, pp. 5913-22 (1998)
- Label or Dye
-
Coumarin
- Product Size
-
800 × 20 µl assays
- Target Enzyme
-
Serine⁄Threonine Kinases
- Validated Kinases
-
PAK2, PAK3, PAK4, PAK6, PAK7, RPS6KA6
- Number of Reactions
-
800 Reactions
- Substrate Properties
-
Peptide-Based Substrate
- Protein or Peptide Source
-
synthetic peptide substrate for NDR1 (KKRNRRLSVA)
- Excitation⁄Emission (nm)
-
405⁄465, 535
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
Fluorescein-Crosstide Substrate
See all Kinase & Phosphatase Substrates
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| PV3509 | 1 mg | 655.00 |
Description
A general substrate for Ser/Thr kinases, the Crosstide peptide substrate is based upon GSK-3alpha/beta.
For use in combination with the LanthaScreen™ Tb-pCrosstide
View full product details >
General Specifications
- Gene ID
-
10000, 10298, 207, 208, 25400, 51347, 5566, 56164, 57144, 6197, 6198, 8536
- Substrate
-
Fluorescein-Crosstide
- Label or Dye
-
FITC (Fluorescein)
- Product Size
-
1 mg
- Target Enzyme
-
Serine⁄Threonine Kinases
- Substrate Type
-
Kinase Substrate
- Detection Method
-
Fluorescent
- Molecular Weight
-
1524 Da
- Validated Kinases
-
AKT1, AKT2, AKT3, CAMK2A, CAMK2D, PAK1, PAK4, PAK7, PRKACA, RPS6KB1, RPS6KA3, TAOK3
- Amino Acid Sequence
-
Fluorescein- GRPRTSSFAEG
- Substrate Properties
-
Peptide-Based Substrate
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Cell Analysis
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
Omnia® S/T Peptide 5 Kit
| Catalog # | Unit Size | List Price | |
|---|---|---|---|
| KNZ1051 | 1 Kit | 901.00 |
Description
The Omnia® kinase assay utilizes peptide substrates incorporating the proprietary SOX moiety to measure phosphorylation in an antibody-free format. This enables the user to View full product details >
General Specifications
- Form
-
Frozen
- Color
-
Green
- Readout
-
Kinetic
- Platform
-
Microplate Reader
- Technique
-
Fluorescence Intensity
- Assay Type
-
Serine⁄Threonine Kinase Assay
- References
-
Nature Methods Vol 2 pps 277-283 (2005) and JACS Vol 125 pps 14248 - 14249 (2003)
- Label or Dye
-
Sox Chelation-Enhanced Fluorophore
- Product Size
-
1 Kit
- Target Enzyme
-
Serine/Threonine Kinases
- Substrate Type
-
Kinase Substrate
- Detection Method
-
Fluorescent
- Molecular Weight
-
1532.3 Da
- Validated Kinases
-
PAK1, PAK2, PAK3, PAK4, PAK7, PKA, PRKG1, PRKG2, PRKX, ROCK2, RPS6KA5 (MSK1)
- Amino Acid Sequence
-
Ac-GRTGRRNSIdP(Sox)G-NH2
- Substrate Properties
-
Peptide-Based Substrate
- Excitation⁄Emission (nm)
-
360⁄485
- Shipping Condition
-
Dry Ice
- Regulatory Statement
-
For Research Use Only. Not for use in diagnostic procedures.
Product Applications
- Drug Discovery & Development
- Proteins, Expression, Isolation & Analysis
User Ratings
PAK4 LanthaScreen Binding Assay Validation Packet
Manual / Product Insert
PAK4 LanthaScreen Activity Assay Validation Packet
Manual / Product Insert
PAK4 Recombinant Human Protein
MSDS
Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin.
Citations & References
- Authors: Dan C; Kelly A; Bernard O; Minden A;
- Journal: J Biol Chem (2001) 276:32115-32136
- Product Usage: pFASTBAC/HT and pFASTBAC-1 vectors were used to transfect with Sf9 cells with Cellfectin.
- ID: PN45078
The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.
Citations & References
- Authors: Gnesutta N, Qu J, Minden A
- Journal: J Biol Chem (2001) 276:14414-14419
- Product Usage:
- ID: PN42721
