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Gene-Related Products
Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis.
Citations & References
- Authors: Escalante M, Courtney J, Chin WG, Teng KK, Kim JI, Fajardo JE, Mayer BJ, Hempstead BL, Birge RB
- Journal: J Biol Chem (2000) 275:24787-24797
- Product Usage:
- ID: PN38170
- Catalog #s
- R415
42a7e8017ab9578358f118300f4720fb_Citations
The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling.
Citations & References
- Authors: Beitner-Johnson D; Blakesley V A; Shen-Orr Z; Jimenez M; Stannard B; Wang L M; Pierce J; LeRoith D;
- Journal: J Biol Chem (1996) 271:9287-9377
- Product Usage: HEK 293 and NIH 3T3 cells were transfected with 10 ug of either pCXN2-CRK II or the pCXN2 vector using the LipofectAMINE reagent, according to the manufacturer's recommended conditions. Selection in 0.5 mg/ml G418 began 48 h after transfection. After 2-3 weeks of selection in G418, individual colonies were isolated.
- ID: PN62302
75f9d915e39f44976c05951f8511b977_Citations
Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk.
Citations & References
- Authors: Blakesley VA, Beitner-Johnson D, Van Brocklyn JR, Rani S, Shen-Orr Z, Stannard BS, Spiegel S, LeRoith D
- Journal: J Biol Chem (1997) 272:16211-16215
- Product Usage:
- ID: PN27811
428e4a840a0bdd12d309983c53a248a8_Citations
Adaptor Protein Crk Induces Src-Dependent Activation of p38 MAPK in Regulation of Synovial Sarcoma Cell Proliferation
Citations & References
- Authors: Watanabe, T; Tsuda, M; Tanaka, S; Ohba, Y; Kawaguchi, H; Majima, T; Sawa, H; Minami, A
- Journal: MOLECULAR CANCER RESEARCH 2009 9:1582-1592
- Product Usage: SYBR® Green Reagents
- ID: PN108659
9741234e4a3262ee5a25e380019c1a6f_Citations
v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation.
Citations & References
- Authors: Akagi T, Shishido T, Murata K, Hanafusa H,
- Journal: Proc Natl Acad Sci U S A (2000) 97:7290-7295
- Product Usage: WB
- ID: PN68530
e441bb87cb73f43eac84e966ea0b47b2_Citations
CCKA receptor activation stimulates p130(Cas) tyrosine phosphorylation, translocation, and association with Crk in rat pancreatic acinar cells.
Citations & References
- Authors: Ferris HA, Tapia JA, García LJ, Jensen RT
- Journal: Biochemistry (1999) 38:1497-1508
- Product Usage:
- ID: PN32293
df139a4a0fe80d9221879c923a2f2162_Citations
Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.
Citations & References
- Authors: Brábek J, Constancio SS, Siesser PF, Shin NY, Pozzi A, Hanks SK,
- Journal: Mol Cancer Res (2005) 3:307-315
- Product Usage: WB with lysates of normal and transfected mouse embryo fibroblasts
- ID: PN131747
5981ab90764b604ad472efed4f5e17c0_Citations
Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs.
Citations & References
- Authors: Polte TR, Hanks SK
- Journal: J Biol Chem (1997) 272:5501-5509
- Product Usage: DNA transfections of COS-7 cells were carried out using LipofectAMINE. Briefly, 5 µg of total plasmid DNA was mixed with 25 µl of LipofectAMINE for transfection of 100-mm cell culture dishes. Cells were incubated 6 h in the presence of LipofectAMINE and DNA in serum-free media before adding calf serum to 10% and incubated an additional 18 h before changing to normal growth media. Cells were harvested 48 h after initial transfection.
- ID: PN62068
38e609e1b3f2028b6f96a1312ee7cec1_Citations
Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes.
Citations & References
- Authors: Kain KH, Klemke RL
- Journal: J Biol Chem (2001) 276:16185-16192
- Product Usage:
- ID: PN44375
a5a01195b62ec3932464c27c412ccab1_Citations
Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold.
Citations & References
- Authors: Cho SY, Klemke RL
- Journal: J Cell Biol (2002) 156:725-736
- Product Usage:
- ID: PN46211
4f734c273514a8b004aa22f37189f8c6_Citations
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway.
Citations & References
- Authors: Noren NK, Foos G, Hauser CA, Pasquale EB
- Journal: Nat Cell Biol (2006) 8:815-825
- Product Usage:
- ID: PN58072
45f6a4a57549a5720dfdcdf643c78b83_Citations
A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport.
Citations & References
- Authors: Gual P, Shigematsu S, Kanzaki M, Grémeaux T, Gonzalez T, Pessin JE, Le Marchand-Brustel Y, Tanti JF
- Journal: J Biol Chem (2002) 277:43980-43986
- Product Usage:
- ID: PN55138
0fe53ab665b7845ea7be17becdd77850_Citations
Methamphetamine causes coordinate regulation of Src, Cas, Crk, and the Jun N-terminal kinase-Jun pathway.
Citations & References
- Authors: Jayanthi S; McCoy MT; Ladenheim B; Cadet JL
- Journal: Molecular Pharmacology 2002 5:1124-1131
- Product Usage: AmpliTaq Gold® Reagents
- ID: PN88892
03c1840715b939090a6160f27d666ec3_Citations
The integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk coupling.
Citations & References
- Authors: Mielenz D, Hapke S, Pöschl E, von Der Mark H, von Der Mark K
- Journal: J Biol Chem (2001) 276:13417-13426
- Product Usage:
- ID: PN42703
4d2356339f13e4b3d5aec55ba88a6019_Citations
