Apaf1 is required for mitochondrial pathways of apoptosis and brain development.

Citations & References

  • Authors: Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R, Penninger JM, Mak TW
  • Journal: Cell (1998) 94:739-750
  • Product Usage: Used pCRII to generate a 400 bp Apaf1 cDNA probe using both T7 and SP6 promoters.
  • ID: PN65348
Catalog #s
K206001
7ef23fd1ad0dc25fcf0f9a0e0da93655_Citations

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

Citations & References

  • Authors: Fortin A, Cregan SP, MacLaurin JG, Kushwaha N, Hickman ES, Thompson CS, Hakim A, Albert PR, Cecconi F, Helin K, Park DS, Slack RS
  • Journal: J Cell Biol (2001) 155:207-216
  • Product Usage:
  • ID: PN45341
Catalog #s
H1398
H21491
H3569
L22172
L2911
L2912
L2916
L3224
f925407353b2aaefee1a0c3b31be5fc1_Citations

Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific.

Citations & References

  • Authors: Ho AT, Li QH, Hakem R, Mak TW, Zacksenhaus E
  • Journal: EMBO J (2004) 23:460-472
  • Product Usage:
  • ID: PN55716
Catalog #s
M22425
4f164cf233807fc02da06599a1264dee_Citations

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.

Citations & References

  • Authors: Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J.
  • Journal: J Biol Chem (2002) 277:29874-29954
  • Product Usage: COS-7L cells were co-transfected in 12-well (22-mm) plates using LipofectAMINE 2000 transfection reagent with plasmids encoding mouse pro-IL-1 and indicated expression plasmids.
  • ID: PN62821
Catalog #s
11668019
77e8db907380e5d3997fe840c6578cbe_Citations

Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells

Citations & References

  • Authors: De Zio, D; Ferraro, E; D'Amelio, M; Simoni, V; Bordi, M; Soroldoni, D; Berghella, L; Meyer, BI; Cecconi, F
  • Journal: CELLULAR AND MOLECULAR LIFE SCIENCES 2008 11:1780-1790
  • Product Usage: Silencer® siRNAs
  • ID: PN81036
Catalog #s
9436ef454060c573ed26a00235a50296_Citations

Array Plate: Human TNFR1 Pathway (XLS)

Manual / Product Insert

Catalog #s
4414190
2b0499a38c552014f2ff4a1df8abe8d2_Manuals

Array Plate: Human Apoptotic Pathways Triggered by HIV1 (XLS)

Manual / Product Insert

Catalog #s
4414106
9d223e2d11d76ac6197ba7f4018bf006_Manuals

Apoptosis Matching TaqMan Assays

Manual / Product Insert

Catalog #s
4482571
65c57c59b1c396fb0bee33d21a7fe822_Manuals

Array Plate: Human c-Myc and Apoptosis (XLS)

Manual / Product Insert

Catalog #s
4414113
156b84a86601888c714c58079409a07e_Manuals

4378701 Plate Info

Manual / Product Insert

Catalog #s
4378701
fc524d9465535e3f32c487236668155f_Manuals

Information Card: Human Apoptosis Array

Manual / Product Insert

Catalog #s
4378701
77382415bbfc9bcb5b2f5b5f5724406c_Manuals

Brochures & Specifications: TaqMan® Human Apoptosis Array

Product Literature

81b3833e2504647f9d794f7d7b9bf341_Brochures

Array Plate: Human Apoptosis (XLS)

Manual / Product Insert

Catalog #s
4414072
300137efca1cc59de0df2f7416fe1cb1_Manuals

Human Apoptosis

Manual / Product Insert

Catalog #s
4414072
4418717
e735c2e2f0eda0a7eddc67a21cbebea6_Manuals