Qdot Serine⁄Threonine Kinases
MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes.
Catalog: PV4902
Size: 10 µg
Size: 10 µg
PKN1 (PRK1) belongs to the protein kinase C superfamily. This kinase is activated by the Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can also be activated by phospholipids.
Catalog: PV3790
Size: 10 µg
Size: 10 µg
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
Catalog: PV5106
Size: 10 µg
Size: 10 µg
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with CyclinC.
Catalog: PV4402
Size: 10 µg
Size: 10 µg
MAP2K1 (MEK1) kinse is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx.
Catalog: PV4003
Size: 1 mg
Size: 1 mg
STK17A (DRAK1) is a serine⁄threonine kinase localized in the nucleus and involved in apoptosis.
Catalog: PV4061
Size: 1 mg
Size: 1 mg
PIM2 is a proto-oncogene which phosphorylates BAD, which partially inhibits its apopotopic function.
Catalog: PV4036
Size: 1 mg
Size: 1 mg
NEK6 controls the initiation of mitosis and is required for the metaphase-anaphase transition.
Catalog: PV4028
Size: 1 mg
Size: 1 mg
The PKC family of serine⁄threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.
Catalog: PV3604
Size: 1 mg
Size: 1 mg
The PKC family of serine⁄threonine kinases, including PRKCB1 (PKC beta I), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.
Catalog: PV3601
Size: 1 mg
Size: 1 mg
DYRK3 belongs to the DYRK family of dual-specificity protein kinases that catalyze phosphorylation of serine⁄threonine and tyrosine residues. The members of this family share structural similarity, but differ in their substrate specificity, suggesting their involvement in different cellular functions.
Catalog: PV3998
Size: 1 mg
Size: 1 mg
CAMKK1 (CAMKKA) is a serine⁄threonine protein kinase family member, and belongs to the Ca2+⁄calmodulin-dependent protein kinase subfamily.
Catalog: PV4671
Size: 1 mg
Size: 1 mg
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease, including the I2020T mutation in the kinase catalytic domain. Related Links: • LRRK2 tools for advancing Parkinson's disease research • Kinase protein portfolio • LanthaScreen® Eu Kinase Binding Assay • LanthaScreen® Activity Assay
Catalog: PV5855
Size: 1 mg
Size: 1 mg
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1.
Catalog: PV5838
Size: 1 mg
Size: 1 mg
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with CyclinC.
Catalog: PV4345
Size: 1 mg
Size: 1 mg
NLK is a serine⁄threonine kinase involved in signal transduction and cellular communication.
Catalog: PV4328
Size: 1 mg
Size: 1 mg
SGK (SGK1) is a serine⁄threonine kinase that may be a transcriptional target for p38⁄MAPK in hepatoma cells.
Catalog: PV4056
Size: 1 mg
Size: 1 mg
MAP2K1 (MEK1) kinse is a dual-specific protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. This mutant has been activated by subsituting serines 218 and 222 with aspartic acid to mimic the phosphorylated state.
Catalog: PV4004
Size: 1 mg
Size: 1 mg
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Catalog: PR7489B
Size: 100 µg
Size: 100 µg
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
Catalog: PV5107
Size: 1 mg
Size: 1 mg
Qdot Serine⁄Threonine Kinases
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