Leukocyte Receptor Tyrosine Kinase
KDR (VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors.
Catalog: PV3660
Size: 10 µg
Size: 10 µg
FLT4 (VEGFR3), a receptor tyrosine kinase, is a key regulator of embryonic blood vessel development and adult angiogenesis. This kinase has been implicated in juvenile hemangioma, kaposi sarcoma, lymphangiomas, and hereditary lymphedemia.
Catalog: PR7216B
Size: 100 µg
Size: 100 µg
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. The Y791F mutant has been observed clinical in association with cancer.
Catalog: PR8194A
Size: 100 µg
Size: 100 µg
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. The PDGFRA V561D mutation is observed in gastrointestinal stromal tumors (GIST).
Catalog: PR7732A
Size: 100 µg
Size: 100 µg
EPHA1 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system.
Catalog: PR7498A
Size: 100 µg
Size: 100 µg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
Catalog: PV4880
Size: 1 mg
Size: 1 mg
EPHB2 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation.
Catalog: PV4101
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L858R mutation is implicated in epithelial tumor formation.
Catalog: PV4289
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics.
Catalog: PV4190
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The T790M mutant of EGFR has arisen in the clinics and displays resistance to Erlotinib (Tarceva) and Gefitinib (Iressa).
Catalog: PV4804
Size: 1 mg
Size: 1 mg
EPHB3 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation.
Catalog: PV4102
Size: 1 mg
Size: 1 mg
FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
Catalog: PV4107
Size: 1 mg
Size: 1 mg
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers.
Catalog: PV4094
Size: 1 mg
Size: 1 mg
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine subfamily that includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation.
Catalog: PV4104
Size: 1 mg
Size: 1 mg
KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. The clinically observed V654A mutant has been demonstrated to be resistant to inhibition with imatinib.
Catalog: PV4291
Size: 1 mg
Size: 1 mg
FGFR1 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
Catalog: PV4105
Size: 1 mg
Size: 1 mg
FGFR2 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
Catalog: PV4106
Size: 1 mg
Size: 1 mg
MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn.
Catalog: PV4113
Size: 1 mg
Size: 1 mg
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family.
Catalog: PV4108
Size: 1 mg
Size: 1 mg
IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGFR has been implicated in a variety of cancers.
Catalog: PV3592
Size: 1 mg
Size: 1 mg
Leukocyte Receptor Tyrosine Kinase
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