Hepatocyte Nuclear Factor 4 Alpha
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
Catalog: PV5106
Size: 10 µg
Size: 10 µg
This is a purified rabbit anti-human p50 oligoclonal antibody that can be use in the validated applications of indirect ELISA, Western blot, and immunocytochemistry. Antibody characteristics include: Applications: This p50 Oligoclonal Antibody, ABfinity™ Recombinant has been validated for use in indirect ELISA, Western blot and immunocytochemistry. Host species and isotype: This is a recombinant rabbit oligoclonal IgG against human p50. Clone ID of monoclonal antibody (mAb): The p50 oligoclonal antibody clone is 24HCLC. Reactivity: Along with human p50, this oligoclonal antibody is predicted t...
Catalog: 710450
Size: 100 µg
Size: 100 µg
This is a purified rabbit anti-human smooth muscle actin oligoclonal antibody that can be use in the validated applications of indirect ELISA and Western blot. Antibody characteristics include: Applications: This Smooth Muscle Actin Oligoclonal Antibody, ABfinity™ Recombinant has been validated for use in indirect ELISA and Western blot Host species and isotype: This is a recombinant rabbit oligoclonal IgG against human smooth muscle actin. Clone ID of oligoclonal antibody (mAb): The smooth muscle actin oligoclonal antibody clone is 17HCLC. Reactivity: Along with human smooth muscle actin , th...
Catalog: 710460
Size: 100 µg
Size: 100 µg
Cryopreserved human hepatocytes for use in transporter-mediated uptake applications. Cells per vial: 4-8 million Prototypical hepatic uptake transporter substrates taurocholate and estradiol-17β-glucuronide have been assessed to qualify the transport function of hepatic NTCP (SLC10A1) and OATP1B14/3 (SLCO1B1/3), respectively. The transport of each substrate (radiolabeled) was monitored by scintillation analysis and active transport values (37°C - 4°C) determined by linear regression. Get the Results You Need with GIBCO® Hepatocytes High quality hepatocytes, with high viabilities, in vivo -like...
Catalog: HMCPUS
Size: 1.5 ml
Size: 1.5 ml
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV4544: The LanthaScreen™ TR-FRET ER alpha Coactivator Assay Kit provides a sensitive and robust method for high-throughput screening of potential estrogen receptor (ER) alpha ligands as agonists or antagonists of ligand-dependent coactivator recruitment. The kit uses a terbium (Tb)-labeled anti-GST antibody, a fluorescein-labeled coactivator peptide, and an ER alpha ligand-binding domain (ER alpha-LBD) that is tagged with glutathione-S-transferase (GST), in a homogenous mix-and-read assay format. Agonist m...
Catalog: A15125
Size: 800 × 20 µl assays
Size: 800 × 20 µl assays
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV6042: The LanthaScreen™ TR-FRET ER beta Competitive Binding Assay provides a sensitive and robust method for high-throughput screening (HTS) of ligands for estrogen receptor beta (ER beta). The kit uses a terbium-labeled anti-GST antibody, a fluorescent small-molecule ER ligand (Fluormone™ ES2), and a human ER beta ligand-binding domain (LBD) that is tagged with glutathione S-transferase (GST), in a homogeneous mix-and-read assay format.
Catalog: A15149
Size: 800 × 20 µl assays
Size: 800 × 20 µl assays
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV4663: The LanthaScreen™ ERR (estrogen related receptor) alpha TR-FRET Coactivator Assay provides a sensitive and robust method for high-throughput screening of potential ERR alpha ligands as inverse agonists (sometimes referred to as antagonists) of coactivator displacement. The kit uses a terbium (Tb)-labeled anti-GST antibody, a fluorescein-labeled coactivator peptide, and an ERR alpha ligand-binding domain (ERR alpha-LBD) that is tagged with glutathione-S-transferase (GST), in a homogeneous mix-and-rea...
Catalog: A15130
Size: 800 × 20 µl assays
Size: 800 × 20 µl assays
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV4655: The LanthaScreen™ TR-FRET LXR (liver X receptor) alpha Coactivator Assay provides a sensitive and robust method for high-throughput screening of potential LXR alpha ligands as agonists of coactivator recruitment. The kit uses a terbium (Tb)-labeled anti-GST antibody, a fluorescein-labeled coactivator peptide, and an LXR alpha ligand-binding domain (LBD) that is tagged with glutathione-S-transferase (GST), in a homogeneous mix-and-read assay format. In the LanthaScreen™ TR-FRET LXR alpha Coactivator ...
Catalog: A15128
Size: 800 × 20 µl assays
Size: 800 × 20 µl assays
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV4684: The LanthaScreen™ TR-FRET PPAR (peroxisome proliferator activated receptor) alpha Coactivator Assay provides a sensitive and robust method for high-throughput screening of potential PPAR alpha ligands as agonists or antagonists of ligand-dependent coactivator recruitment. The kit uses a terbium (Tb)-labeled anti-GST antibody, a fluorescein-labeled coactivator peptide, and a human recombinant PPAR alpha ligand-binding domain (PPAR alpha-LBD) that is tagged with glutathione-S-transferase (GST) in a ho...
Catalog: A15133
Size: 800 × 20 µl assays
Size: 800 × 20 µl assays
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV4892: The LanthaScreen™ TR-FRET PPAR alpha Competitive Binding Assay provides a sensitive and robust method for high-throughput screening (HTS) of ligands for peroxisome proliferator-activated receptor alpha (PPAR alpha). The kit uses a terbium-labeled anti-GST antibody, a fluorescent small-molecule pan-PPAR ligand (Fluormone™ Pan-PPAR Green), and a human PPAR alpha ligand-binding domain (LBD) that is tagged with glutathione S-transferase (GST), in a homogeneous mix-and-read assay format. To assay: When r...
Catalog: A15143
Size: 400 × 40 µl assays
Size: 400 × 40 µl assays
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV4409: The LanthaScreen™ TR-FRET Retinoic Acid Receptor (RAR) alpha Coactivator Assay Kit provides a sensitive and robust method for high-throughput screening of potential RAR alpha ligands as agonists of coactivator recruitment. The homogeneous mix-and-read assay format results in a ligand EC50 composite value representing the amount of ligand required to bind to receptor, effect a conformational change, and recruit coactivator peptide (Figure 1). How it works The LanthaScreen™ TR-FRET RAR alpha Coactivat...
Catalog: A15122
Size: 800 × 20 µl assays
Size: 800 × 20 µl assays
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV5889: The LanthaScreen™ TR-FRET Retinoid-related Orphan Receptor alpha (ROR alpha) Coactivator Assay Kit provides a sensitive and robust method for high-throughput screening of potential ROR alpha ligands as agonists or inverse agonists of coactivator recruitment. The homogeneous mix-and-read assay uses a terbium (Tb)-labeled anti-GST antibody, a fluorescein-labeled coactivator peptide, and a ROR alpha ligand-binding domain (ROR alpha-LBD) that is tagged with glutathione-S-transferase (GST).
Catalog: A15146
Size: 800 × 20 µl assays
Size: 800 × 20 µl assays
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV4797: The LanthaScreen™ TR-FRET Retinoid X Receptor alpha Coactivator Assay provides a sensitive and robust method for high-throughput screening of potential RXR alpha ligands as agonists of ligand-dependent coactivator recruitment. The kit uses a terbium (Tb)-labeled anti- GST antibody, a fluorescein-labeled coactivator peptide, and a human recombinant RXR alpha ligand-binding domain (RXR alpha-LBD) that is tagged with glutathione-S-transferase (GST) in a homogeneous mix-and-read assay format. To assay: ...
Catalog: A15138
Size: 800 × 20 µl assays
Size: 800 × 20 µl assays
This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV4687: The LanthaScreen™ TR-FRET TR (thyroid receptor) alpha Coactivator Assay Kit provides a sensitive and robust method for highthroughput screening of potential TR alpha ligands as agonists of ligand-dependent coactivator recruitment. The kit uses a terbium (Tb)-labeled anti-GST antibody, a fluorescein-labeled coactivator peptide, and a human recombinant TR alpha ligand-binding domain (TR alpha-LBD) that is tagged with glutathione-S-transferase (GST) in a homogeneous, mix-and-read assay format. To Assay...
Catalog: A15136
Size: 800 × 20 µl assays
Size: 800 × 20 µl assays
TCR ALPHA BETA, Hamster Anti-Mouse, (Alexa Fluor 488); Alexa Fluor 488 conjugated Monoclonal antibody specific to Mouse TCR α/β. This antibody is validated for use in Flow Cytometry. Anti-TCR α/β recognizes the expressed product of the TCRA/B gene.
Catalog: HM3620
Size: 1 ml
Size: 1 ml
PDGFRALPHA [pY742] PAb; Unconjugated Polyclonal antibody specific to Mouse, (Human, Rat) PDGFRα [pY742]. This antibody is validated for use in Western Blot. Anti-PDGFRα [pY742] recognizes the expressed product of the Pdgfra gene.
Catalog: 44-1006
Size: 10 blots
Size: 10 blots
Gibco® Hepatocyte Thaw Media is a ready-to-use media specifically designed for use with thawed cryopreserved hepatocytes to enhance their viability and overall quality. This media is provided in a 50 mL conical tube for ease of use. Features of Hepatocyte Thaw Media: • Easy to use—simply warm up to 37°C and add thawed hepatocytes • Recover cryopreserved hepatocytes with a single centrifugation • Designed for use with Gibco® human and animal cryopreserved hepatocytes for optimal results • Provides high quality hepatocytes suitable for many in vitro assays, including induction, metabolic stabili...
Catalog: CM7500
Size: 50 ml
Size: 50 ml
The cationic mitochondrial dye, 4-Di-2-ASP is a styryl with a large Stokes shift. It can also be used to stain presyntptic nerve terminals independent of neuronal activity.
Catalog: D-289
Size: 1 g
Size: 1 g
The Vybrant Apoptosis Assay Kit #4 detects apoptosis on the basis of changes that occur in the permeability of cell membranes. This kit contains ready-to-use solutions of both YO-PRO-1 and propidium iodide nucleic acid stains. YO-PRO-1 stain selectively passes through the plasma membranes of apoptotic cells and labels them with moderate green fluorescence. Necrotic cells are stained red-fluorescent with propidium iodide.
Catalog: V13243
Size: 1 kit
Size: 1 kit
DASPMI (4-Di-1-ASP) is a styryl dye stains mitochondria of live cells. This dye has a large fluorescence Stokes shift and is taken up relatively slowly as a function of membrane potential.
Catalog: D-288
Size: 1 g
Size: 1 g
Hepatocyte Nuclear Factor 4 Alpha
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