Cytoplasmic Tyrosine Kinases
Breast tumor kinase (Brk) is a non-receptor protein tyrosine kinase expressed in over 60% of breast carcinoma tissue samples and breast tumor cell lines.
Catalog: PR4375B
Size: 100 µg
Size: 100 µg
SRMS (Srm) is a tyrosine protein kinase (SRC sub-family) that may be involved in the proliferation and differentiation of keratinocytes.
Catalog: PR7031A
Size: 100 µg
Size: 100 µg
MATK (Hyl) is a non-receptor CSK-type protein tyrosine kinase that is thought to function in signal transduction pathways important in megakaryocyte growth and⁄or differentiation.
Catalog: PR5045A
Size: 100 µg
Size: 100 µg
FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory.
Catalog: PR4163A
Size: 1 mg
Size: 1 mg
LCK is a SRC-related kinase family expressed in lymphocytes.
Catalog: PR4170A
Size: 100 µg
Size: 100 µg
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. SRCN1 is a neuronal splice variant of SRC.
Catalog: PR2886A
Size: 100 µg
Size: 100 µg
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2.
Catalog: PV4288
Size: 1 mg
Size: 1 mg
Bone marrow tyrosine kinase (BMX) is a non-receptor tyrosine kinase that belongs to the SRC-related TEC subfamily of tyrosine kinases. It is an important regulator of various cellular processes including apoptosis, cell survival, cellular differentiation, cell migration, and transformation.
Catalog: PV4074
Size: 1 mg
Size: 1 mg
TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other types of receptors.
Catalog: PV5861
Size: 1 mg
Size: 1 mg
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The G250E mutant is a Gleevec resistant form of ABL1.
Catalog: PV4183
Size: 1 mg
Size: 1 mg
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway.
Catalog: PV4568
Size: 1 mg
Size: 1 mg
LYN is a SRC family kinase expressed predominantly in hematopoietic cells. Activation of LYN has been shown to lead to imatinib resistance in CML patients. LYNB and the slightly shorter LYNA are the two isoforms of LYN.
Catalog: PV4082
Size: 1 mg
Size: 1 mg
ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation.
Catalog: PR3017A
Size: 1 mg
Size: 1 mg
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The E255K mutant is a Gleevec resistant form of ABL1.
Catalog: PR7420A
Size: 100 µg
Size: 100 µg
Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha⁄beta and -gamma signal transduction pathways.
Catalog: PR8767C
Size: 100 µg
Size: 100 µg
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth.
Catalog: PR4336E
Size: 100 µg
Size: 100 µg
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The Y253F mutant is a Gleevec resistant form of ABL1.
Catalog: PR7444A
Size: 100 µg
Size: 100 µg
FES (FPS) is a tyrosine protein kinase that is required for maintenance of cellular transformation. Its chromosomal location is linked to a specific translocation event identified in patients with acute promyelocytic leukemia, and it is also involved in normal hematopoiesis.
Catalog: PR5068B
Size: 100 µg
Size: 100 µg
ITK is a tyrosine kinase expressed in T-cells which contains both SH2 and SH3 domains. ITK is thought to play a role in T-cell proliferation and differentiation.
Catalog: PR6992A
Size: 100 µg
Size: 100 µg
CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene.
Catalog: PV4075
Size: 1 mg
Size: 1 mg
Cytoplasmic Tyrosine Kinases
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