Products from Melk Recombinant Human Protein to Txk Recombinant Human Protein
MELK is a serine⁄threonione kinase which is related to the AMPK family that has been linked to the cell cycle. MELK has also been shown to be overexpressed in cancer and has been identified has a potential target for cancer therapeutics.
Catalog: PV4824
Size: 1 mg
Size: 1 mg
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease. Related Links: • LRRK2 tools for advancing Parkinson's disease research • Kinase protein portfolio • LanthaScreen® Eu Kinase Binding Assay • LanthaScreen® Activity Assay
Catalog: PV4874
Size: 1 mg
Size: 1 mg
IKBKE is an activator of nuclear factor-kappa-B. Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death.
Catalog: PV4876
Size: 1 mg
Size: 1 mg
Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors
Catalog: PV4878
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
Catalog: PV4880
Size: 1 mg
Size: 1 mg
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease. The G2019S mutation of LRRK2 is associated with an increase in catalytic activity. Related Links: • LRRK2 tools for advancing Parkinson's disease research • Kinase protein portfolio • LanthaScreen® Eu Kinase Binding Assay • LanthaScreen® Activity Assay
Catalog: PV4882
Size: 1 mg
Size: 1 mg
Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1, similar to other type 1 receptors, has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2.
Catalog: PV4884
Size: 1 mg
Size: 1 mg
MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes.
Catalog: PV4902
Size: 10 µg
Size: 10 µg
MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes.
Catalog: PV4903
Size: 1 mg
Size: 1 mg
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
Catalog: PV5106
Size: 10 µg
Size: 10 µg
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
Catalog: PV5107
Size: 1 mg
Size: 1 mg
PIK3C3 (hVPS34) is the sole class III member of the PI3 Kinase family. PIK3C3 phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 3-phosphate [PI(3)P], which recruits downstream effectors containing FYVE and Phox domains to membranes. PIK3C3 is involved in coupling nutrient signaling to mTOR and also plays a role in autophagy and intracellular trafficking.
Catalog: PV5127
Size: 1 mg
Size: 1 mg
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signalling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapuetics for the treatment of cancer.
Catalog: PV5215
Size: 1 mg
Size: 1 mg
SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine producing the signalling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapuetics for the treatment of cancer.
Catalog: PV5217
Size: 1 mg
Size: 1 mg
PIK3CD (p110 delta) is a class IA PI3K that elicits signaling cascasdes by phosphorylation of the 3 position of PIP2. Unlike the widely expressed Class IA alpha and beta enzymes, the delta isoform is expressed primarily in leukocytes. PIK3CD is coexpressed and copurified with the regulatory subunit PIK3R1.
Catalog: PV5274
Size: 1 mg
Size: 1 mg
HIPK2 is a nuclear serine⁄threonine kinase that is linked to transcriptional regulation and apoptosis.
Catalog: PV5276
Size: 1 mg
Size: 1 mg
PI4KB and PI4KA are the two human type III PI4 kinases, which share sequence similarly with PI3 kinases and phosphorylate the 4 position of phosphotidyl inositol.
Catalog: PV5277
Size: 20 µg
Size: 20 µg
PI4KB and PI4KA are the two human type III PI4 kinases, which share sequence similarly with PI3 kinases and phosphorylate the 4 position of phosphotidyl inositol.
Catalog: PV5278
Size: 1 mg
Size: 1 mg
The class II PI3 kinases, including PIK3C2B, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the class I PI3 kinases, the class II enyzmes have been linked to diverse, recpetor-mediated cellular processes including insulin signalling, neuronal survival, and growth factor signalling.
Catalog: PV5375
Size: 1 mg
Size: 1 mg
The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enyzmes have been linked to diverse, recpetor-mediated cellular processes including insulin signalling, neuronal survival, and growth factor signalling.
Catalog: PV5587
Size: 1 mg
Size: 1 mg
The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases, regulate protein synthesis by phosphroylation eIF4E on Ser209, and may contribute to tumorigenesis.
Catalog: PV5608
Size: 1 mg
Size: 1 mg
PI4KB and PI4KA are the two human type III PI4 kinases, which share sequence similarly with PI3 kinases and phosphorylate the 4 position of phosphotidyl inositol.
Catalog: PV5690
Size: 1 mg
Size: 1 mg
Matched and validated lipid and peptide substrates are available to complement the Adapta® Universal Kinase Assay. The assays developed with these reagents allow for primary or secondary screening of kinase inhibitors.
Catalog: PV5707
Size: 1 ml
Size: 1 ml
GSG2 (haspin) is a conserved kinase required for mitosis. GSG2 phosphorylates histone H3 and is viewed as a potential therapeutic target for oncology.
Catalog: PV5709
Size: 1 mg
Size: 1 mg
PDK4 (PDHK4), along with the other PDHKs, regulates glucose metabolism by phosphorylating the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex. Inhhibition of PDHKs is viewed as a potential therapeutic treament for type II diabetes.
Catalog: PV5711
Size: 1 mg
Size: 1 mg
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1.
Catalog: PV5838
Size: 1 mg
Size: 1 mg
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease, including the I2020T mutation in the kinase catalytic domain. Related Links: • LRRK2 tools for advancing Parkinson's disease research • Kinase protein portfolio • LanthaScreen® Eu Kinase Binding Assay • LanthaScreen® Activity Assay
Catalog: PV5855
Size: 1 mg
Size: 1 mg
EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme.
Catalog: PV5857
Size: 1 mg
Size: 1 mg
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease, including the R1441C mutation in the GTPase domain. Related Links: • LRRK2 tools for advancing Parkinson's disease research • Kinase protein portfolio • LanthaScreen® Eu Kinase Binding Assay • LanthaScreen® Activity Assay
Catalog: PV5859
Size: 1 mg
Size: 1 mg
TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other types of receptors.
Catalog: PV5861
Size: 1 mg
Size: 1 mg
Products from Melk Recombinant Human Protein to Txk Recombinant Human Protein
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