Products from Map4k2 (Gck) Recombinant Human Protein to Mylk (Mlck) Recombinant Human Protein
MAP4K2 (GCK) is a serine⁄ threonine protein kinase that activates the JNK pathway. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal center, where it may participate in B-cell differentiation. The kinase may also play a role in the regulation of vesicle targeting or fusion.
Catalog: PV4281
Size: 1 mg
Size: 1 mg
NEK1 is a serine⁄threonine protein kinase, related to the NIMA cell cycle regulator, and is highly expressed in meiotic germ cells. The kinase may function early in the DNA damage response pathway. NEK1 may also participate in polycystic kidney disease and neural cell development.
Catalog: PV4282
Size: 1 mg
Size: 1 mg
NUAK1 (ARK5) is a serine⁄threonine kinase that plays a role in many cellular functions. The overexpression of this kinase has been associated with tumor invasion and metastasis (colorectal neoplasm).
Catalog: PV4283
Size: 1 mg
Size: 1 mg
PAK4 is a serine⁄ threonine p21 activating kinase implicated in the reorganization of actin cytoskeleton and in the formation of filopodia.
Catalog: PV4284
Size: 1 mg
Size: 1 mg
PBK (TOPK) is a serine⁄threonine kinase that is related to the dual specific mitogen-activated protein kinase kinase (MAPKK). The kinase is up-regulated in a variety of hematological malignancies, participates in activating lymphoid cells, and supports testicular function (spermatogenesis).
Catalog: PV4285
Size: 1 mg
Size: 1 mg
PLK2 is a serum inducible serine⁄threonine kinase that is a member of the polo family of serine⁄threonine kinases which have a role in normal cell division. The kinase may play a role in embryogenesis, wound healing, and neoplasia.
Catalog: PV4286
Size: 1 mg
Size: 1 mg
SRMS (Srm) is a tyrosine protein kinase (SRC sub-family) that may be involved in the proliferation and differentiation of keratinocytes.
Catalog: PV4287
Size: 1 mg
Size: 1 mg
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2.
Catalog: PV4288
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L858R mutation is implicated in epithelial tumor formation.
Catalog: PV4289
Size: 1 mg
Size: 1 mg
FLT4 (VEGFR3), a receptor tyrosine kinase, is a key regulator of embryonic blood vessel development and adult angiogenesis. This kinase has been implicated in juvenile hemangioma, kaposi sarcoma, lymphangiomas, and hereditary lymphedemia.
Catalog: PV4290
Size: 1 mg
Size: 1 mg
KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. The clinically observed V654A mutant has been demonstrated to be resistant to inhibition with imatinib.
Catalog: PV4291
Size: 1 mg
Size: 1 mg
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. PDGFRA D842V is expressed in a high percentage of epithelial ovarian cancers and is implicated in the pathogenesis of acute myelogenous leukemia.
Catalog: PV4292
Size: 1 mg
Size: 1 mg
CAMKK2 (CaMKK beta) is a serine⁄threonine kinase involved in neurogenesis, cell differentiation, and signal transduction. It also activates CAMKI and CAMKIV, and plays a role in the development of long term memory.
Catalog: PV4322
Size: 1 mg
Size: 1 mg
DCAMKL2 is a serine⁄threonine kinase involved in signal transduction and cellular communication, and is the human homolog of a rat protein kinase expressed in cerebrocortical lamination that binds microtubules.
Catalog: PV4323
Size: 1 mg
Size: 1 mg
HIPK3 is a serine⁄threonine kinase involved in signal transduction, cellular communication, and multidrug resistance of tumors and plays a role in the phosphorylation of FADD.
Catalog: PV4324
Size: 1 mg
Size: 1 mg
RIPK2 is a serine⁄threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis.
Catalog: PV4325
Size: 1 mg
Size: 1 mg
SRPK1 is a serine⁄threonine kinase that plays a role in the regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors.
Catalog: PV4326
Size: 1 mg
Size: 1 mg
CHUK (IKK alpha) is a serine⁄threonine kinase involved in signal transduction and cellular communication. It belongs to the cytokine activated protein complex that is an inhibitor of the NF-kappa B complex.
Catalog: PV4327
Size: 1 mg
Size: 1 mg
NLK is a serine⁄threonine kinase involved in signal transduction and cellular communication.
Catalog: PV4328
Size: 1 mg
Size: 1 mg
ACVR1B is a serine⁄threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas.
Catalog: PV4329
Size: 1 mg
Size: 1 mg
MAP3K8 (COT) is a serine⁄threonine kinase which can activate both the MAP and JNK kinase pathways and plays a role in the cell cycle.
Catalog: PV4330
Size: 1 mg
Size: 1 mg
NEK4 is a serine⁄threonine kinase involved in signal transduction and cellular communication. It is proposed to act exclusively upon threonine residues and is present in most primary carcinomas.
Catalog: PV4331
Size: 1 mg
Size: 1 mg
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility.
Catalog: PV4332
Size: 1 mg
Size: 1 mg
BRSK1 (SAD1) is a serine⁄threonine kinase, and is a UV-induced DNA damage checkpoint kinase
Catalog: PV4344
Size: 1 mg
Size: 1 mg
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with CyclinC.
Catalog: PV4345
Size: 1 mg
Size: 1 mg
CDK9 is a serine⁄threonine kinase that phosphorylates the c-terminal domain of the largest subunit of RNA polymerase II and is involved in cell cycle regulation, This protein is coexpressed and copurified with CyclinK.
Catalog: PV4346
Size: 1 mg
Size: 1 mg
JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. This kinase contains both the JH1 (catalytic) and JH2 (pseudokinase) domains of JAK2. The V617F mutation has been shown to be a cause of polycythemia vera.
Catalog: PV4347
Size: 1 mg
Size: 1 mg
LIMK1 is a serine⁄threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK1 has also been implicated in brain development.
Catalog: PV4348
Size: 1 mg
Size: 1 mg
LIMK2 is a serine⁄threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK2 has also been implicated in brain development.
Catalog: PV4349
Size: 1 mg
Size: 1 mg
MYLK (MLCK) is a serine⁄threonine kinase that phosphorylates myosin regulatory light chains to assist in the production of contractile activity (myosin-actin interaction).
Catalog: PV4350
Size: 1 mg
Size: 1 mg
Products from Map4k2 (Gck) Recombinant Human Protein to Mylk (Mlck) Recombinant Human Protein
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