Products from Aurkc (Aurora C) Recombinant Human Protein to Cdk9⁄Cyclin T1 Recombinant Human Protein
AURKC (Aurora C) is a chromosomal passenger protein that forms complexes with AURKB (Aurora B) and inner centromere proteins, playing a role in organizing microtubules in relation to centrosome⁄spindle function during mitosis. It is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction.
Catalog: PV4178
Size: 1 mg
Size: 1 mg
ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. It is throught to be involved in the early formation of the chondrocytes and cartilage and growth plate development.
Catalog: PV4179
Size: 1 mg
Size: 1 mg
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The Y253F mutant is a Gleevec resistant form of ABL1.
Catalog: PV4181
Size: 1 mg
Size: 1 mg
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The E255K mutant is a Gleevec resistant form of ABL1.
Catalog: PV4182
Size: 1 mg
Size: 1 mg
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The G250E mutant is a Gleevec resistant form of ABL1.
Catalog: PV4183
Size: 1 mg
Size: 1 mg
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The T315I mutant is a Gleevec resistant form of ABL1.
Catalog: PV4184
Size: 1 mg
Size: 1 mg
The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Catalog: PV4186
Size: 1 mg
Size: 1 mg
KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis. KIT T670I is a Gleevec resistant form of KIT.
Catalog: PV4187
Size: 1 mg
Size: 1 mg
DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec.
Catalog: PV4188
Size: 1 mg
Size: 1 mg
Dual-specificity kinases, such as DYRK4, play key roles in cell proliferation, survival, and development.
Catalog: PV4189
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics.
Catalog: PV4190
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L861Q mutation is an Iressa-responsive mutant observed in the clinic.
Catalog: PV4191
Size: 1 mg
Size: 1 mg
FRK (PTK5) is a nuclear protein and may function during G1 and S phase of the cell cycle, suppressing growth.
Catalog: PV4192
Size: 1 mg
Size: 1 mg
ITK is a tyrosine kinase expressed in T-cells which contains both SH2 and SH3 domains. ITK is thought to play a role in T-cell proliferation and differentiation.
Catalog: PV4193
Size: 1 mg
Size: 1 mg
MAP3K3 (MEKK3) directly regulates MAPK8 and extracellular signal-regulated protein kinase (ERK) pathways by phosphorylating multiple MAP2Ks.
Catalog: PV4194
Size: 1 mg
Size: 1 mg
MAP3K10 (MLK2) is a serine⁄threonine kinase which has been shown to activate MAPK8⁄JNK and MKK4⁄SEK1. This kinase itself can be phoshorylated, and is thus activated by JNK kinases. MAP3K10 functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Catalog: PV4195
Size: 1 mg
Size: 1 mg
MARK2 is a serine⁄threonine protein kinase involved in the control of cell polarity and microtubule stability.
Catalog: PV4196
Size: 1 mg
Size: 1 mg
PKN2 (PRK2), a close relative of the PKCs, is a regulator of mitosis and exit from cytokinesis.
Catalog: PV4197
Size: 1 mg
Size: 1 mg
STK23 (MSSK1), also known as SRPK3, is a muscle-specific member of the SRPKs.
Catalog: PV4198
Size: 1 mg
Size: 1 mg
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations.
Catalog: PV4199
Size: 1 mg
Size: 1 mg
ZAK is a leucine zipper-containing mitogen-activated protein related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks.
Catalog: PV4200
Size: 1 mg
Size: 1 mg
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The FLT3 D835Y mutant is a drug resistant form of FLT3.
Catalog: PV4271
Size: 1 mg
Size: 1 mg
MET (cMET) is a receptor-like tyrosine kinase whose disregulation has been linked to many types of human malignancies. The M1250T mutant of MET is both activating and displays altered substrate specificity.
Catalog: PV4272
Size: 1 mg
Size: 1 mg
DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon induced programmed cell death and is a potential tumour suppressor.
Catalog: PV4273
Size: 1 mg
Size: 1 mg
Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation.
Catalog: PV4275
Size: 1 mg
Size: 1 mg
PASK is an evolutionarily conserved protein present in yeast, flies, and mammals. PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli.
Catalog: PV4276
Size: 1 mg
Size: 1 mg
PRKG2 (PKG2) exhibits many cellular functions and has cAMP- and cGMP-dependent protein kinase activity.
Catalog: PV4277
Size: 1 mg
Size: 1 mg
CAMK2B (CaMKII beta) is a serine⁄threonine kinase that plays a role in synaptic plasticity, synaptic vesicle mobilization and regulation of gene expression. As a dominant kinase in the central nervous system it may function in long term potentiation and neurotransmitter release.
Catalog: PV4278
Size: 1 mg
Size: 1 mg
CLK2 is a serine⁄threonine kinase that phosphorylates serine⁄arginine-rich proteins as related to controlling RNA splicing. It is also thought to link cell cycle progression, apoptosis, and telomere length regulation.
Catalog: PV4279
Size: 1 mg
Size: 1 mg
CDK9 is a serine⁄threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1.
Catalog: PV4280
Size: 1 mg
Size: 1 mg
Products from Aurkc (Aurora C) Recombinant Human Protein to Cdk9⁄Cyclin T1 Recombinant Human Protein
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