Products from Mark1 (Mark) Recombinant Human Protein to Cdk5⁄P25 Recombinant Human Protein
MARK1 (MARK) is a serine⁄threonine kinase which is involved in cytoskeletal organization and biogenesis
Catalog: PR8034A
Size: 100 µg
Size: 100 µg
BRSK1 (SAD1) is a serine⁄threonine kinase, and is a UV-induced DNA damage checkpoint kinase
Catalog: PR8037A
Size: 100 µg
Size: 100 µg
The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases, regulate protein synthesis by phosphroylation eIF4E on Ser209, and may contribute to tumorigenesis.
Catalog: PR8046A
Size: 100 µg
Size: 100 µg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The T790M mutant of EGFR has arisen in the clinics and displays resistance to Erlotinib (Tarceva) and Gefitinib (Iressa).
Catalog: PR8052A
Size: 100 µg
Size: 100 µg
CDK4 functions as a cell-cycle initiator protein. This protein is coexpressed and copurified with CyclinD1.
Catalog: PR8064A
Size: 100 µg
Size: 100 µg
CDC42BPA (MRCKA) is a serine⁄threonine kinase which functions in actin cytoskeleton assembly and organization.
Catalog: PR8067A
Size: 100 µg
Size: 100 µg
CDC42BPB is a serine⁄threonine kinases which functions in actin cytoskeleton assembly and organization.
Catalog: PR8070A
Size: 100 µg
Size: 100 µg
JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains both the JH1 (catalytic) and JH2 (pseudokinase) domains of JAK2.
Catalog: PR8078A
Size: 100 µg
Size: 100 µg
LTK (TYK1) is a member of the ros⁄insulin receptor family of kinases involved in cell growth and differentiation.
Catalog: PR8108A
Size: 100 µg
Size: 100 µg
JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. This kinase contains both the JH1 (catalytic) and JH2 (pseudokinase) domains of JAK2. The V617F mutation has been shown to be a cause of polycythemia vera.
Catalog: PR8134A
Size: 100 µg
Size: 100 µg
IL-1 receptor associated kinases (IRAKs) are serine⁄threonine kinases involved in signaling via Toll⁄IL-1 pathways.
Catalog: PR8140B
Size: 100 µg
Size: 100 µg
PAK7 (KIAA1264) is implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling.
Catalog: PR8143A
Size: 100 µg
Size: 100 µg
FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. The K650E mutation leads to constitutive activation and the neonatal lethal disorder TDII.
Catalog: PR8155A
Size: 100 µg
Size: 100 µg
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway.
Catalog: PR8161B
Size: 100 µg
Size: 100 µg
RPS6KA6 (RSK4) is a member of the RSK kinases family. RSK family members are activated by ERKs and mitogens and are unusual in that they contain 2 non-identical kinase domains.
Catalog: PR8170A
Size: 100 µg
Size: 100 µg
NEK11 (FLJ23495) belongs to the NIMA family of kinases which are involved in DNA replication and genotoxic stress response.
Catalog: PR8182A
Size: 100 µg
Size: 100 µg
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. The Y791F mutant has been observed clinical in association with cancer.
Catalog: PR8194A
Size: 100 µg
Size: 100 µg
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. The V804L mutant has been observed in association with cancer.
Catalog: PR8200A
Size: 100 µg
Size: 100 µg
PDK4 (PDHK4), along with the other PDHKs, regulates glucose metabolism by phosphorylating the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex. Inhhibition of PDHKs is viewed as a potential therapeutic treament for type II diabetes.
Catalog: PR8253A
Size: 100 µg
Size: 100 µg
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine⁄threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.
Catalog: PR8265A
Size: 100 µg
Size: 100 µg
NEK9 belongs to the NIMA family of kinases which are involved in DNA replication and genotoxic stress response.
Catalog: PR8280A
Size: 100 µg
Size: 100 µg
HIPK1 phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors.
Catalog: PR8290A
Size: 100 µg
Size: 100 µg
CAMKK1 (CAMKKA) is a serine⁄threonine protein kinase family member, and belongs to the Ca2+⁄calmodulin-dependent protein kinase subfamily.
Catalog: PR8308A
Size: 100 µg
Size: 100 µg
DYRK1B is a member of the DYRK family of protein kinases and is proposed to be involved in nuclear functions.
Catalog: PR8350A
Size: 100 µg
Size: 100 µg
SNF1LK2 (QIK) is a serine⁄threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family.
Catalog: PR8353A
Size: 100 µg
Size: 100 µg
AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabet...
Catalog: PR8376C
Size: 100 µg
Size: 100 µg
CDK6 functions as a cell-cycle initiator protein. This protein is coexpressed and copurified with CyclinD1.
Catalog: PR8422B
Size: 100 µg
Size: 100 µg
Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling.
Catalog: PR8440C
Size: 100 µg
Size: 100 µg
EEF2K is a highly conserved Serine⁄Threoning kinase in the calmodulin signaling pathway whose activity is increased in cancers including breast cancer.
Catalog: PR8535A
Size: 100 µg
Size: 100 µg
CDK5 plays a critical role in neuron development. The disregulation of the CDK5 and the truncated activator p25 is believed to be involved in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Amyotrophic Lateral Sclerosis. This protein is coexpressed and copurified with p25.
Catalog: PR8543B
Size: 100 µg
Size: 100 µg
Products from Mark1 (Mark) Recombinant Human Protein to Cdk5⁄P25 Recombinant Human Protein
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