Products from Lrrk2 [I2020t] Human Protein to Mapkapk2 Recombinant Human Protein
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease, including the I2020T mutation in the kinase catalytic domain. Related Links: • LRRK2 tools for advancing Parkinson's disease research • Kinase protein portfolio • LanthaScreen® Eu Kinase Binding Assay • LanthaScreen® Activity Assay
Catalog: PV5855
Size: 1 mg
Size: 1 mg
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1.
Catalog: PR9075A
Size: 100 µg
Size: 100 µg
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1.
Catalog: PV5838
Size: 1 mg
Size: 1 mg
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with CyclinC.
Catalog: PR7261B
Size: 100 µg
Size: 100 µg
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with CyclinC.
Catalog: PV4345
Size: 1 mg
Size: 1 mg
NLK is a serine⁄threonine kinase involved in signal transduction and cellular communication.
Catalog: PR7525A
Size: 100 µg
Size: 100 µg
NLK is a serine⁄threonine kinase involved in signal transduction and cellular communication.
Catalog: PV4328
Size: 1 mg
Size: 1 mg
SGK (SGK1) is a serine⁄threonine kinase that may be a transcriptional target for p38⁄MAPK in hepatoma cells.
Catalog: PR7358A
Size: 100 µg
Size: 100 µg
SGK (SGK1) is a serine⁄threonine kinase that may be a transcriptional target for p38⁄MAPK in hepatoma cells.
Catalog: PV4056
Size: 1 mg
Size: 1 mg
MAP2K1 (MEK1) kinse is a dual-specific protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. This mutant has been activated by subsituting serines 218 and 222 with aspartic acid to mimic the phosphorylated state.
Catalog: PR3944C
Size: 100 µg
Size: 100 µg
MAP2K1 (MEK1) kinse is a dual-specific protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. This mutant has been activated by subsituting serines 218 and 222 with aspartic acid to mimic the phosphorylated state.
Catalog: PV4004
Size: 1 mg
Size: 1 mg
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Catalog: PR7489A
Size: 1 mg
Size: 1 mg
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Catalog: PR7489B
Size: 100 µg
Size: 100 µg
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
Catalog: PR8985A
Size: 100 µg
Size: 100 µg
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
Catalog: PV5107
Size: 1 mg
Size: 1 mg
The proto-oncogene PIM1 is upregulated in prostate cancer.
Catalog: PR5298A
Size: 1 mg
Size: 1 mg
The proto-oncogene PIM1 is upregulated in prostate cancer.
Catalog: PR5298C
Size: 100 µg
Size: 100 µg
RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylates and activates the serine⁄threonine specific protein kinases ERK1 and ERK2. The RAF1 Y340D Y341D mutant is constitutively active.
Catalog: PR7307A
Size: 100 µg
Size: 100 µg
RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylates and activates the serine⁄threonine specific protein kinases ERK1 and ERK2. The RAF1 Y340D Y341D mutant is constitutively active.
Catalog: PV4046
Size: 1 mg
Size: 1 mg
AKT2 is a phosphoinositide-dependent serine⁄threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone.
Catalog: PR4640B
Size: 100 µg
Size: 100 µg
AKT2 is a phosphoinositide-dependent serine⁄threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone.
Catalog: PV3975
Size: 1 mg
Size: 1 mg
AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabet...
Catalog: PR8376C
Size: 100 µg
Size: 100 µg
RIPK5 is a serine⁄threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis.
Catalog: PR8626A
Size: 100 µg
Size: 100 µg
RIPK5 is a serine⁄threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis.
Catalog: PV4679
Size: 1 mg
Size: 1 mg
DCAMKL2 is a serine⁄threonine kinase involved in signal transduction and cellular communication, and is the human homolog of a rat protein kinase expressed in cerebrocortical lamination that binds microtubules.
Catalog: PR7853A
Size: 100 µg
Size: 100 µg
DCAMKL2 is a serine⁄threonine kinase involved in signal transduction and cellular communication, and is the human homolog of a rat protein kinase expressed in cerebrocortical lamination that binds microtubules.
Catalog: PV4323
Size: 1 mg
Size: 1 mg
WNK2 is a serine⁄threonine kinase involved in signal transduction and cellular communication
Catalog: PR8019A
Size: 100 µg
Size: 100 µg
WNK2 is a serine⁄threonine kinase involved in signal transduction and cellular communication
Catalog: PV4352
Size: 1 mg
Size: 1 mg
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation.
Catalog: PR5320A
Size: 100 µg
Size: 100 µg
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation.
Catalog: PV4019
Size: 1 mg
Size: 1 mg
Products from Lrrk2 [I2020t] Human Protein to Mapkapk2 Recombinant Human Protein
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