Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
RPS6KB1 (p70S6K) is a serine⁄threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein.
Catalog: PV4054
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
NEK7 belongs to the NIMA family of kinases which are involved in DNA replication and genotoxic stress response.
Catalog: PV4029
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
MAP3K7 (TAK1) controls transcription regulation and apoptosis, and is implicated in inflammatory disease and rheumatoid arthritis. Fusion of MAP3K7 to MAP3K7IP1 (TAB1) activates MAP3K7.
Catalog: PV4430
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
Casein kinase II is a protein serine⁄threonine kinase that is thought to be present in all eukarotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing 2 alpha or alpha-prime subunits (or one of each) and 2 beta subunits. The function of beta subunits is unknown and the alpha subunit is the catalytic unit.
Catalog: PV3993
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Cytoplasmic Tyrosine Kinases
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth.
Catalog: PV3584
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
GRK6 is a member of the guanine nucleotide-binding protein coupled receptor kinase subfamily of the serine⁄threonine protein kinase family. GRK6 phosphorylates the activated forms of G protein-coupled receptors to initiate their deactivation.
Catalog: PV4001
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
PAK1 is a serine⁄threonine kinase that is a target for restenosis, cancer, and immunosuppression treatment.
Catalog: PV4030
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
SNF1LK2 (QIK) is a serine⁄threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family.
Catalog: PV4793
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
MAP3K10 (MLK2) is a serine⁄threonine kinase which has been shown to activate MAPK8⁄JNK and MKK4⁄SEK1. This kinase itself can be phoshorylated, and is thus activated by JNK kinases. MAP3K10 functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Catalog: PV4195
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
HIPK1 phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors.
Catalog: PV4562
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
PDK1 (3-phosphoinositide dependent kinase-1) is a serine⁄threonine protein kinase localized to the plasma membrane. It plays a vital role in insulin-induced glycogen synthesis, PKC activation, and activation of the AGC subfamily of protein kinases.
Catalog: PV4033
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
TAOK2 (TAO1) is a serine⁄threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway.
Catalog: PV4068
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Receptor Tyrosine Kinases
KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis.
Catalog: PV3589
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
EEF2K is a highly conserved Serine⁄Threoning kinase in the calmodulin signaling pathway whose activity is increased in cancers including breast cancer.
Catalog: PV4560
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Receptor Tyrosine Kinases
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. The V804L mutant has been observed in association with cancer.
Catalog: PV4433
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Receptor Tyrosine Kinases
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations.
Catalog: PV4199
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
PRKACA (PKA) is a serine⁄threonine protein kinase that phosphorylates a broad spectrum of substrates. PRKACA regulates many cellular processes including cell growth, cell differentiation, ion-channel conductivity, gene transcription, and synaptic release of neurotransmitters.
Catalog: PV4040
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
SGKL (SGK3) is a serine⁄threonine protein kinase which is similar to serum- and glucocorticoid-induced protein kinase (SGK). Unlike SGK, SGKL is not induced by serum or glucocorticoids. It is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK.
Catalog: PV4058
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
MARK2 is a serine⁄threonine protein kinase involved in the control of cell polarity and microtubule stability.
Catalog: PV4196
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Receptor Tyrosine Kinases
MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease.
Catalog: PV4112
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
RPS6KA5 (MSK1) is a serine⁄threonine protein kinase that is essential for the regulation of various cellular processes.
Catalog: PV4053
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Receptor Tyrosine Kinases
TYRO3 is a receptor tyrosine kinase that has been shown to be involved in signal transduction and cell adhesion.
Catalog: PV4121
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Cytoplasmic Tyrosine Kinases
FES (FPS) is a tyrosine protein kinase that is required for maintenance of cellular transformation. Its chromosomal location is linked to a specific translocation event identified in patients with acute promyelocytic leukemia, and it is also involved in normal hematopoiesis.
Catalog: PV4077
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Receptor Tyrosine Kinases
ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor.
Catalog: PV4120
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
MAPK8 (JNK1) is activated by the presence of malfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity.
Catalog: PV3593
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Receptor Tyrosine Kinases
EPHA7 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA7 is involved in embryonic development.
Catalog: PV4098
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
This recombinant fusion protein consists of full-length glycogen synthase kinase 3 alpha (GSK3A) and a glutathione S-transferase (GST) tag. It is validated in the LanthaScreen® Eu Kinase Binding Assay. No special measures were taken to activate this kinase. • Compatible and validated with the LanthaScreen® Eu Kinase Binding Assay • Expressed in insect cells • GST tagged for use with Eu-labeled GST antibody Easily Screen for Kinase Binding The LanthaScreen® Eu Kinase Binding Assay is a TR-FRET assay that lets you measure inhibitor binding to non-activated kinases, perform simple off-rate measur...
Catalog: PV6127
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Receptor Tyrosine Kinases
PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene.
Catalog: PV3591
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
MAP3K3 (MEKK3) directly regulates MAPK8 and extracellular signal-regulated protein kinase (ERK) pathways by phosphorylating multiple MAP2Ks.
Catalog: PV4194
Size: 1 mg
Category: Products & Services > Proteins, Enzymes, & Peptides > Kinases > Serine⁄Threonine Kinases
PAK4 is a serine⁄ threonine p21 activating kinase implicated in the reorganization of actin cytoskeleton and in the formation of filopodia.
Catalog: PV4284
Size: 1 mg