Products from Prkcb1 (Pkc Beta I) Recombinant Human Protein to Phkg1 Recombinant Human Protein
The PKC family of serine⁄threonine kinases, including PRKCB1 (PKC beta I), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.
Catalog: PV3601
Size: 1 mg
Size: 1 mg
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1.
Catalog: PV5838
Size: 1 mg
Size: 1 mg
MATK (Hyl) is a non-receptor CSK-type protein tyrosine kinase that is thought to function in signal transduction pathways important in megakaryocyte growth and⁄or differentiation.
Catalog: PV4084
Size: 1 mg
Size: 1 mg
FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory.
Catalog: PR4163A
Size: 1 mg
Size: 1 mg
LCK is a SRC-related kinase family expressed in lymphocytes.
Catalog: PV4081
Size: 1 mg
Size: 1 mg
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. The PDGFRA V561D mutation is observed in gastrointestinal stromal tumors (GIST).
Catalog: PV4681
Size: 1 mg
Size: 1 mg
NLK is a serine⁄threonine kinase involved in signal transduction and cellular communication.
Catalog: PV4328
Size: 1 mg
Size: 1 mg
SGK (SGK1) is a serine⁄threonine kinase that may be a transcriptional target for p38⁄MAPK in hepatoma cells.
Catalog: PV4056
Size: 1 mg
Size: 1 mg
EPHA1 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system.
Catalog: PV4093
Size: 1 mg
Size: 1 mg
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Catalog: PR7489A
Size: 1 mg
Size: 1 mg
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
Catalog: PV5107
Size: 1 mg
Size: 1 mg
The proto-oncogene PIM1 is upregulated in prostate cancer.
Catalog: PR5298A
Size: 1 mg
Size: 1 mg
RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylates and activates the serine⁄threonine specific protein kinases ERK1 and ERK2. The RAF1 Y340D Y341D mutant is constitutively active.
Catalog: PV4046
Size: 1 mg
Size: 1 mg
AKT2 is a phosphoinositide-dependent serine⁄threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone.
Catalog: PV3975
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
Catalog: PV4880
Size: 1 mg
Size: 1 mg
DCAMKL2 is a serine⁄threonine kinase involved in signal transduction and cellular communication, and is the human homolog of a rat protein kinase expressed in cerebrocortical lamination that binds microtubules.
Catalog: PV4323
Size: 1 mg
Size: 1 mg
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2.
Catalog: PV4288
Size: 1 mg
Size: 1 mg
WNK2 is a serine⁄threonine kinase involved in signal transduction and cellular communication
Catalog: PV4352
Size: 1 mg
Size: 1 mg
EPHB2 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation.
Catalog: PV4101
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L858R mutation is implicated in epithelial tumor formation.
Catalog: PV4289
Size: 1 mg
Size: 1 mg
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation.
Catalog: PV4019
Size: 1 mg
Size: 1 mg
The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enyzmes have been linked to diverse, recpetor-mediated cellular processes including insulin signalling, neuronal survival, and growth factor signalling.
Catalog: PV5587
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics.
Catalog: PV4190
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The T790M mutant of EGFR has arisen in the clinics and displays resistance to Erlotinib (Tarceva) and Gefitinib (Iressa).
Catalog: PV4804
Size: 1 mg
Size: 1 mg
IL-1 receptor associated kinases (IRAKs) are serine⁄threonine kinases involved in signaling via Toll⁄IL-1 pathways.
Catalog: PV4002
Size: 1 mg
Size: 1 mg
RPS6KA3 (RSK2) is a serine⁄threonine kinase that modulates many cellular processes including transcription, adhesion, growth, survival, and proliferation.
Catalog: PV4051
Size: 1 mg
Size: 1 mg
CHEK2 (CHK2) is a serine⁄threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in this gene has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins.
Catalog: PV3983
Size: 1 mg
Size: 1 mg
EPHB3 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation.
Catalog: PV4102
Size: 1 mg
Size: 1 mg
PIK3CD (p110 delta) is a class IA PI3K that elicits signaling cascasdes by phosphorylation of the 3 position of PIP2. Unlike the widely expressed Class IA alpha and beta enzymes, the delta isoform is expressed primarily in leukocytes. PIK3CD is coexpressed and copurified with the regulatory subunit PIK3R1.
Catalog: PV5274
Size: 1 mg
Size: 1 mg
PHKG1 is a serine⁄threonine kinase with glycogenolytic regulatory functions.
Catalog: PV4034
Size: 1 mg
Size: 1 mg
Products from Prkcb1 (Pkc Beta I) Recombinant Human Protein to Phkg1 Recombinant Human Protein
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