Products from Acvrl1 (Alk1) Recombinant Human Protein to Camk4 (Camkiv) Recombinant Human Protein
Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1, similar to other type 1 receptors, has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2.
Catalog: PR8914A
Size: 100 µg
Size: 100 µg
This recombinant fusion protein consists of the catalytic domain of transforming growth factor beta receptor 2 (TGFBR2) and glutathione S-transferase (GST) tag. It is validated in the LanthaScreen® Eu Kinase Binding Assay. No special measures were taken to activate this kinase. • Compatible and validated with the LanthaScreen® Eu Kinase Binding Assay • Expressed in insect cells • GST tagged for use with Eu-labeled GST antibody Easily Screen for Kinase Binding The LanthaScreen® Eu Kinase Binding Assay is a TR-FRET assay that lets you measure inhibitor binding to non-activated kinases, perform s...
Catalog: PR9171A
Size: 100 µg
Size: 100 µg
WEE1, which is classified as a Ser⁄Thr kinase by sequence analysis, has been shown to inactivate multiple CDKs by tyrosine phosphorylation.
Catalog: PR7373A
Size: 100 µg
Size: 100 µg
ADRBK1 (GRK2) is a serine⁄threonine kinase. Many of the G protein-coupled receptors are known to be phosphorylated by G protein-dependent receptor kinases (GRKs)
Catalog: PR4694C
Size: 100 µg
Size: 100 µg
RPS6KA6 (RSK4) is a member of the RSK kinases family. RSK family members are activated by ERKs and mitogens and are unusual in that they contain 2 non-identical kinase domains.
Catalog: PR8170A
Size: 100 µg
Size: 100 µg
MAPK12 (p38 gamma) is a serine⁄threonine kinase involved in many different cellular processes. It is activated during hypoxia and gamma-irradiation-induced G(2) arrest.
Catalog: PR6830A
Size: 100 µg
Size: 100 µg
LIMK1 is a serine⁄threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK1 has also been implicated in brain development.
Catalog: PR7844A
Size: 100 µg
Size: 100 µg
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine subfamily that includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation.
Catalog: PR6308B
Size: 100 µg
Size: 100 µg
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway.
Catalog: PR8161B
Size: 100 µg
Size: 100 µg
EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme.
Catalog: PR9072A
Size: 100 µg
Size: 100 µg
MLCK (MLCK2), now also known as MYLK3, is of of the myosin regulatory light chain kinases which facilitates muscle contraction.
Catalog: PR7174A
Size: 100 µg
Size: 100 µg
KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. The clinically observed V654A mutant has been demonstrated to be resistant to inhibition with imatinib.
Catalog: PR7738A
Size: 100 µg
Size: 100 µg
PKN2 (PRK2), a close relative of the PKCs, is a regulator of mitosis and exit from cytokinesis.
Catalog: PR7370A
Size: 100 µg
Size: 100 µg
BRSK1 (SAD1) is a serine⁄threonine kinase, and is a UV-induced DNA damage checkpoint kinase
Catalog: PR8037A
Size: 100 µg
Size: 100 µg
DMPK is a serine⁄threonine kinase expressed in various muscle and nerve tissues. Mutations in the untranslated region of the DMPK gene are a characteristic of myotonic dystrophy.
Catalog: PR7186A
Size: 100 µg
Size: 100 µg
FGFR1 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
Catalog: PR4660A
Size: 100 µg
Size: 100 µg
PRKG1 is a cGMP-dependent serine⁄threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation
Catalog: PR8028A
Size: 100 µg
Size: 100 µg
MAPK13 (p38 delta) is a serine⁄threonine kinase that transduces a variety of extracellular signals, including cytokine and environmental stress responses. MAPK13 also regulates the differentiation of keratinocytes.
Catalog: PR6835B
Size: 100 µg
Size: 100 µg
GSG2 (haspin) is a conserved kinase required for mitosis. GSG2 phosphorylates histone H3 and is viewed as a potential therapeutic target for oncology.
Catalog: PR9069A
Size: 100 µg
Size: 100 µg
The PKC family of serine⁄threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.
Catalog: PR7016A
Size: 100 µg
Size: 100 µg
LYN is a SRC family kinase expressed predominantly in hematopoietic cells. Activation of LYN has been shown to lead to imatinib resistance in CML patients. LYNB and the slightly shorter LYNA are the two isoforms of LYN.
Catalog: PR3722B
Size: 100 µg
Size: 100 µg
SRPK2, along with SRPK1, is most likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection. It therefore represents an important host cell target for therapeutic intervention in HBV infection.
Catalog: PR7462A
Size: 100 µg
Size: 100 µg
FGFR2 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
Catalog: PR5332A
Size: 100 µg
Size: 100 µg
MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs.
Catalog: PR5049C
Size: 100 µg
Size: 100 µg
CLK2 is a serine⁄threonine kinase that phosphorylates serine⁄arginine-rich proteins as related to controlling RNA splicing. It is also thought to link cell cycle progression, apoptosis, and telomere length regulation.
Catalog: PR7747B
Size: 100 µg
Size: 100 µg
MAP2K3 (MEK3) is a dual-specificity protein kinase which acts in cellular signal transduction pathways, and is necessary for the expression of glucose transporter.
Catalog: PR6413A
Size: 100 µg
Size: 100 µg
MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn.
Catalog: PR7438A
Size: 100 µg
Size: 100 µg
PLK2 is a serum inducible serine⁄threonine kinase that is a member of the polo family of serine⁄threonine kinases which have a role in normal cell division. The kinase may play a role in embryogenesis, wound healing, and neoplasia.
Catalog: PR7592A
Size: 100 µg
Size: 100 µg
BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron.
Catalog: PR6995A
Size: 100 µg
Size: 100 µg
CAMK4 (CaMKIV) is a serine⁄threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF. It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
Catalog: PR5249B
Size: 100 µg
Size: 100 µg
Products from Acvrl1 (Alk1) Recombinant Human Protein to Camk4 (Camkiv) Recombinant Human Protein
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