Products from Ikbkb (Ikk Beta) Recombinant Human Protein to Eif2ak2 (Pkr) Recombinant Human Protein
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Catalog: PR7489B
Size: 100 µg
Size: 100 µg
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER.
Catalog: PR8985A
Size: 100 µg
Size: 100 µg
The proto-oncogene PIM1 is upregulated in prostate cancer.
Catalog: PR5298C
Size: 100 µg
Size: 100 µg
RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylates and activates the serine⁄threonine specific protein kinases ERK1 and ERK2. The RAF1 Y340D Y341D mutant is constitutively active.
Catalog: PR7307A
Size: 100 µg
Size: 100 µg
AKT2 is a phosphoinositide-dependent serine⁄threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone.
Catalog: PR4640B
Size: 100 µg
Size: 100 µg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
Catalog: PR8911A
Size: 100 µg
Size: 100 µg
DCAMKL2 is a serine⁄threonine kinase involved in signal transduction and cellular communication, and is the human homolog of a rat protein kinase expressed in cerebrocortical lamination that binds microtubules.
Catalog: PR7853A
Size: 100 µg
Size: 100 µg
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2.
Catalog: PR7820B
Size: 100 µg
Size: 100 µg
WNK2 is a serine⁄threonine kinase involved in signal transduction and cellular communication
Catalog: PR8019A
Size: 100 µg
Size: 100 µg
EPHB2 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation.
Catalog: PR6320A
Size: 100 µg
Size: 100 µg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L858R mutation is implicated in epithelial tumor formation.
Catalog: PR7447A
Size: 100 µg
Size: 100 µg
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation.
Catalog: PR5320A
Size: 100 µg
Size: 100 µg
The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enyzmes have been linked to diverse, recpetor-mediated cellular processes including insulin signalling, neuronal survival, and growth factor signalling.
Catalog: PR9053A
Size: 100 µg
Size: 100 µg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics.
Catalog: PR7295B
Size: 100 µg
Size: 100 µg
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The T790M mutant of EGFR has arisen in the clinics and displays resistance to Erlotinib (Tarceva) and Gefitinib (Iressa).
Catalog: PR8052A
Size: 100 µg
Size: 100 µg
IL-1 receptor associated kinases (IRAKs) are serine⁄threonine kinases involved in signaling via Toll⁄IL-1 pathways.
Catalog: PR5612U
Size: 100 µg
Size: 100 µg
RPS6KA3 (RSK2) is a serine⁄threonine kinase that modulates many cellular processes including transcription, adhesion, growth, survival, and proliferation.
Catalog: PR5326A
Size: 100 µg
Size: 100 µg
CHEK2 (CHK2) is a serine⁄threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in this gene has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins.
Catalog: PR5460B
Size: 100 µg
Size: 100 µg
EPHB3 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation.
Catalog: PR6638B
Size: 100 µg
Size: 100 µg
PIK3CD (p110 delta) is a class IA PI3K that elicits signaling cascasdes by phosphorylation of the 3 position of PIP2. Unlike the widely expressed Class IA alpha and beta enzymes, the delta isoform is expressed primarily in leukocytes. PIK3CD is coexpressed and copurified with the regulatory subunit PIK3R1.
Catalog: PR9026C
Size: 100 µg
Size: 100 µg
PHKG1 is a serine⁄threonine kinase with glycogenolytic regulatory functions.
Catalog: PR7319A
Size: 100 µg
Size: 100 µg
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4.
Catalog: PR6983B
Size: 100 µg
Size: 100 µg
MAP3K8 (COT) is a serine⁄threonine kinase which can activate both the MAP and JNK kinase pathways and plays a role in the cell cycle.
Catalog: PR7887A
Size: 100 µg
Size: 100 µg
The PKC family of serine⁄threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.
Catalog: PR1455C
Size: 100 µg
Size: 100 µg
Bone marrow tyrosine kinase (BMX) is a non-receptor tyrosine kinase that belongs to the SRC-related TEC subfamily of tyrosine kinases. It is an important regulator of various cellular processes including apoptosis, cell survival, cellular differentiation, cell migration, and transformation.
Catalog: PR5116C
Size: 100 µg
Size: 100 µg
FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
Catalog: PR4631B
Size: 100 µg
Size: 100 µg
TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other types of receptors.
Catalog: PR9089A
Size: 100 µg
Size: 100 µg
AURKA (Aurora A) is a serine⁄threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer.
Catalog: PR5935A
Size: 100 µg
Size: 100 µg
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers.
Catalog: PR7040A
Size: 100 µg
Size: 100 µg
EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection.
Catalog: PR8917B
Size: 100 µg
Size: 100 µg
Products from Ikbkb (Ikk Beta) Recombinant Human Protein to Eif2ak2 (Pkr) Recombinant Human Protein
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