Products from Lanthascreen™ Stat5 (Jak2 V617f) U2os Cell Line to Nek9 Recombinant Human Protein
LanthaScreen™ GFP Cellular Assays allow for the analysis of post-translational modifications for a number of target proteins in an live-cell context. The JAK2⁄STAT5 signaling pathway plays an essential role in blood cell formation in response to cytokines such as GM-CSF, IL-3, and EPO. The recent discovery of an activating mutation in JAK2 (V617F) present in high percentage of myeloproliferative disease (MPD) patients suggests that this mutant JAK2 activity is a potential therapeutic target for certain forms of MPD. The assay described in this summary makes use of a cell line engineered for ex...
Catalog: K1588
Size: 1 vial
Size: 1 vial
The CellSensor® LEF/TCF-bla SW480 cell line contains a beta-lactamase reporter gene under control of the lymphoid enhancer factor/T cell factor (LEF/TCF) consensus binding sequence stably integrated into SW480 cells, which express a truncated form of the tumor suppressor protein adenomatous polyposis coli (APC). This cell line is a clonal population isolated by flow cytometry, with the pathway validated using RNAi against beta-catenin. The truncated, loss-of-function version of APC expressed in this cell line prevents the proper assembly of the beta-catenin destruction complex. This results in...
Catalog: K1675
Size: 1 vial
Size: 1 vial
Wnt signaling via beta - catenin plays a central role in development and homeostasis. This pathway is invariably disrupted in colorectal tumors and commonly affected by mutation in other cancers. Binding of the Wnt protein to the Frizzled transmembrane receptors initiates a signaling cascade that activates the Dishevelled protein, which then inhibits the serine/threonine kinase Glycogen Synthase - 3 Beta (GSK - 3B). This signal leads to functional inactivation and dissociation of a multiprotein beta - catenin destruction complex made up of the tumor suppressor protein Adenomatous Polyposis Col...
Catalog: K1677
Size: 1 vial
Size: 1 vial
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease. • Increase disease relevance by interrogating a purified and active full-length LRRK2 protein • Uncover novel compounds or hits specific to the full-length form • Advan...
Catalog: A15202PT
Size: 1 mg
Size: 1 mg
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multi-domain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active wild type LRRK2 protein may be useful in research to better understand the native protein, unaffected by mutations, as well as to explore the mechanisms underlying the disease. • Increase disease relevance by interrogating a purified and active full-length LRRK2 protein • Uncover novel compounds or hits specific to the full-length form • Advance Parkinso...
Catalog: A15199PT
Size: 1 mg
Size: 1 mg
This is a workgroup license for Vector NTI® Express Designer that serves up to 10 users who wish to share their data with each other. This license requires an Advanced Support Agreement (A15333). Vector NTI® Express Designer takes you beyond traditional sequence analysis and design and into the new frontier of rational bio-design. Vector NTI® Express Designer was designed for synthetic biology, metabolic engineering, genetic engineering, and molecular biology professionals who want to rationally design, characterize, assemble, re-factor, and reuse genetic "parts," "devices," and "circuits"—ult...
Catalog: A15332
Size: 1 each
Size: 1 each
This sequencing buffer is optimized for use with BigDye® Terminator v1.1 and v3.1 Cycle Sequencing Kits. For Research Use Only. Not for use in diagnostics procedures.
Catalog: 4336701
Size: 233 ml
Size: 233 ml
DYRK3 belongs to the DYRK family of dual-specificity protein kinases that catalyze phosphorylation of serine⁄threonine and tyrosine residues. The members of this family share structural similarity, but differ in their substrate specificity, suggesting their involvement in different cellular functions.
Catalog: PV3998
Size: 1 mg
Size: 1 mg
CAMKK1 (CAMKKA) is a serine⁄threonine protein kinase family member, and belongs to the Ca2+⁄calmodulin-dependent protein kinase subfamily.
Catalog: PV4671
Size: 1 mg
Size: 1 mg
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease, including the I2020T mutation in the kinase catalytic domain. Related Links: • LRRK2 tools for advancing Parkinson's disease research • Kinase protein portfolio • LanthaScreen® Eu Kinase Binding Assay • LanthaScreen® Activity Assay
Catalog: PV5855
Size: 1 mg
Size: 1 mg
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. SRCN1 is a neuronal splice variant of SRC.
Catalog: PV4087
Size: 1 mg
Size: 1 mg
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. The Y791F mutant has been observed clinical in association with cancer.
Catalog: PV4432
Size: 1 mg
Size: 1 mg
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with CyclinC.
Catalog: PV4345
Size: 1 mg
Size: 1 mg
MAP2K1 (MEK1) kinse is a dual-specific protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. This mutant has been activated by subsituting serines 218 and 222 with aspartic acid to mimic the phosphorylated state.
Catalog: PV4004
Size: 1 mg
Size: 1 mg
RIPK5 is a serine⁄threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis.
Catalog: PV4679
Size: 1 mg
Size: 1 mg
Dual-specificity kinases, such as DYRK4, play key roles in cell proliferation, survival, and development.
Catalog: PV4189
Size: 1 mg
Size: 1 mg
CDK6 functions as a cell-cycle initiator protein. This protein is coexpressed and copurified with CyclinD1.
Catalog: PV4437
Size: 1 mg
Size: 1 mg
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The G250E mutant is a Gleevec resistant form of ABL1.
Catalog: PV4183
Size: 1 mg
Size: 1 mg
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease, including the R1441C mutation in the GTPase domain. Related Links: • LRRK2 tools for advancing Parkinson's disease research • Kinase protein portfolio • LanthaScreen® Eu Kinase Binding Assay • LanthaScreen® Activity Assay
Catalog: PV5859
Size: 1 mg
Size: 1 mg
MARK4 is a serine⁄threonine kinase that is likely to be directly involved in microtubule organization in neuronal cells.
Catalog: PV4175
Size: 1 mg
Size: 1 mg
STK25 (YSK1) is a serine⁄threonine kinase that belongs to the GCK family of kinases. It has been implicated as an upstream regulator of MAP kinase signaling pathways.
Catalog: PV4065
Size: 1 mg
Size: 1 mg
NEK4 is a serine⁄threonine kinase involved in signal transduction and cellular communication. It is proposed to act exclusively upon threonine residues and is present in most primary carcinomas.
Catalog: PV4331
Size: 1 mg
Size: 1 mg
NEK1 is a serine⁄threonine protein kinase, related to the NIMA cell cycle regulator, and is highly expressed in meiotic germ cells. The kinase may function early in the DNA damage response pathway. NEK1 may also participate in polycystic kidney disease and neural cell development.
Catalog: PV4282
Size: 1 mg
Size: 1 mg
HIPK4 is a homeodomain-interacting protein kinase and has been demonstrated to phosphorylate p53.
Catalog: PV4176
Size: 1 mg
Size: 1 mg
MAPK3 (ERK1) is a serine⁄threonine kinase that is an important activator of p90, RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway.
Catalog: PV3594
Size: 1 mg
Size: 1 mg
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The E255K mutant is a Gleevec resistant form of ABL1.
Catalog: PV4182
Size: 1 mg
Size: 1 mg
MAP2K6 (MKK6) is a serine⁄threonine kinase that functions as an activator of p38 in the MAPK pathway. The MAP2K6 S207E T211E mutant is constitutively active.
Catalog: PV4008
Size: 1 mg
Size: 1 mg
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. PDGFRA T674I is a Gleevec resistant form of PDGFRA.
Catalog: PV4118
Size: 1 mg
Size: 1 mg
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease. The G2019S mutation of LRRK2 is associated with an increase in catalytic activity. Related Links: • LRRK2 tools for advancing Parkinson's disease research • Kinase protein portfolio • LanthaScreen® Eu Kinase Binding Assay • LanthaScreen® Activity Assay
Catalog: PV4882
Size: 1 mg
Size: 1 mg
NEK9 belongs to the NIMA family of kinases which are involved in DNA replication and genotoxic stress response.
Catalog: PV4654
Size: 1 mg
Size: 1 mg
Products from Lanthascreen™ Stat5 (Jak2 V617f) U2os Cell Line to Nek9 Recombinant Human Protein
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