Products from Csnk1d (Ck1 Δ) Recombinant Human Protein to Pdgfra (Pdgfr Α) Recombinant Human Protein
CSNK1D (CK1 delta), a serine/threonine kinase, plays a critical role in Wnt/beta-catenin signaling pathway. This pathway is important in both development and cancer.
Catalog: PV3987
Size: 1 mg
Size: 1 mg
B-lymphoid tyrosine kinase (BLK) is a non-receptor tyrosine kinase that belongs to the Src family of kinases. BLK plays an important role in B-cell activation.
Catalog: PV4073
Size: 1 mg
Size: 1 mg
TAOK3 (JIK) is a serine⁄threonine kinase that is a member of the GCK-like subfamily of the STE20 kinase family. JIK is ubiquitously expressed in human tissues, inhibits JNK and has been implicated in cancer.
Catalog: PV4069
Size: 1 mg
Size: 1 mg
GRK5 is a serine⁄threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes.
Catalog: PV4000
Size: 1 mg
Size: 1 mg
BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser⁄thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins.
Catalog: PV6039
Size: 1 mg
Size: 1 mg
TTK is a serine⁄threonine kinase closely related to SPK1, PIM 1 and CDC2 serine⁄threonine kinases. TTK is a dual-specificity kinase, which can also phosphorylate tyrosine.
Catalog: PV4071
Size: 1 mg
Size: 1 mg
PLK3 is a member of the polo family of serine⁄threonine kinases. PLK3 is involved in the regulation of M phase in the cell cycle.
Catalog: PV4039
Size: 1 mg
Size: 1 mg
The epidermal growth factor receptor is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L861Q mutation is an Iressa-responsive mutant observed in the clinic.
Catalog: PV4191
Size: 1 mg
Size: 1 mg
INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake.
Catalog: PV4110
Size: 1 mg
Size: 1 mg
STK22D (TSSK1) is a serine⁄threonine kinase essential to the function and production of sperm (spermiogenesis).
Catalog: PV4063
Size: 1 mg
Size: 1 mg
PRKD2 (PKD2) is a member of the protein kinase D serine⁄threonine protein kinase family. PRKD2 is a component in the signal transduction pathway induced by phorbol esters and the CCK b gastrin receptor.
Catalog: PV4042
Size: 1 mg
Size: 1 mg
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. PDGFRA D842V is expressed in a high percentage of epithelial ovarian cancers and is implicated in the pathogenesis of acute myelogenous leukemia.
Catalog: PV4292
Size: 1 mg
Size: 1 mg
CDK1 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF). It is essential for G1⁄S and G2⁄M phase transitions of the eukaryotic cell cycle, and plays important regulatory roles in cell cycle control. This protein is coexpressed and copurified with CyclinB.
Catalog: PV3980
Size: 1 mg
Size: 1 mg
MELK is a serine⁄threonione kinase which is related to the AMPK family that has been linked to the cell cycle. MELK has also been shown to be overexpressed in cancer and has been identified has a potential target for cancer therapeutics.
Catalog: PV4824
Size: 1 mg
Size: 1 mg
PIK3CA (p110 alpha) is known to be involved in the PI 3-kinase⁄AKT signaling pathway, which plays an important role in regulating cell growth and apoptosis. PIK3CA is coexpressed and copurified with the regulatory subunit PI3KR1.
Catalog: PV4789
Size: 1 mg
Size: 1 mg
The PKC family of serine⁄threonine kinases, including PRKCD (PKC delta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.
Catalog: PV3603
Size: 1 mg
Size: 1 mg
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine⁄threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.
Catalog: PV4031
Size: 1 mg
Size: 1 mg
GSK3B is a proline-directed serine⁄threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation.
Catalog: PV3597
Size: 1 mg
Size: 1 mg
This recombinant fusion protein consists of the catalytic domain of transforming growth factor beta receptor 2 (TGFBR2) and glutathione S-transferase (GST) tag. It is validated in the LanthaScreen® Eu Kinase Binding Assay. No special measures were taken to activate this kinase. • Compatible and validated with the LanthaScreen® Eu Kinase Binding Assay • Expressed in insect cells • GST tagged for use with Eu-labeled GST antibody Easily Screen for Kinase Binding The LanthaScreen® Eu Kinase Binding Assay is a TR-FRET assay that lets you measure inhibitor binding to non-activated kinases, perform s...
Catalog: PV6123
Size: 1 mg
Size: 1 mg
NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.
Catalog: PR5995A
Size: 1 mg
Size: 1 mg
FRK (PTK5) is a nuclear protein and may function during G1 and S phase of the cell cycle, suppressing growth.
Catalog: PV4192
Size: 1 mg
Size: 1 mg
CDK5 plays a critical role in neuron development. The disregulation of the CDK5 and the truncated activator p25 is believed to be involved in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Amyotrophic Lateral Sclerosis. This protein is coexpressed and copurified with p25.
Catalog: PV4677
Size: 1 mg
Size: 1 mg
LTK (TYK1) is a member of the ros⁄insulin receptor family of kinases involved in cell growth and differentiation.
Catalog: PV4652
Size: 1 mg
Size: 1 mg
ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and⁄or cytoskeletal reorganization.
Catalog: PV3586
Size: 1 mg
Size: 1 mg
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signalling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapuetics for the treatment of cancer.
Catalog: PV5215
Size: 1 mg
Size: 1 mg
INSRR, insulin receptor-related receptor, is a member of the insulin receptor (IR) family. INSRR does not bind insulin-like molecules, but is similar to INSR in tyrosine kinase activity.
Catalog: PV4111
Size: 1 mg
Size: 1 mg
Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation.
Catalog: PV4275
Size: 1 mg
Size: 1 mg
SRPK1 is a serine⁄threonine kinase that plays a role in the regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors.
Catalog: PV4326
Size: 1 mg
Size: 1 mg
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
Catalog: PR4380A
Size: 1 mg
Size: 1 mg
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family.
Catalog: PV4117
Size: 1 mg
Size: 1 mg
Products from Csnk1d (Ck1 Δ) Recombinant Human Protein to Pdgfra (Pdgfr Α) Recombinant Human Protein
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