Products from Bigdye® Terminator V3.1 Cycle Sequencing Kit to Dyrk3 Recombinant Human Protein
The BigDye® Terminator v3.1 Cycle Sequencing Kit's robust, highly flexible chemistry is ideal for de novo sequencing, resequencing, and finishing with PCR product, Plasmid, Fosmid, and BAC templates. • Improve the quality of your results for a wide range of sequencing applications. • Optimized for long read lengths. • Better dye mobility characteristics • Improved performance reading through GT rich regions. • Get longer, higher-quality reads with more uniform peak heights and optimal signal balance. • Enhance your productivity and reduce costs. Get More Uniform Peak Heights, Improved Accuracy...
Catalog: 4337458
Size: 25000 reactions
Size: 25000 reactions
This is a static, non-expiring site license for Vector NTI® Express Designer. A site license is an efficient way of providing the software to a large number of users within an organization, as opposed to purchasing many individual static or dynamic/seat licences. Vector NTI® Express Designer takes you beyond traditional sequence analysis and design and into the new frontier of rational bio-design. Vector NTI® Express Designer was designed for synthetic biology, metabolic engineering, genetic engineering, and molecular biology professionals who want to rationally design, characterize, assemble,...
Catalog: A15318
Size: 1 each
Size: 1 each
The BigDye® Terminator v3.1 Cycle Sequencing Kit's robust, highly flexible chemistry is ideal for de novo sequencing, resequencing, and finishing with PCR product, Plasmid, Fosmid, and BAC templates. • Improve the quality of your results for a wide range of sequencing applications. • Optimized for long read lengths. • Better dye mobility characteristics • Improved performance reading through GT rich regions. • Get longer, higher-quality reads with more uniform peak heights and optimal signal balance. • Enhance your productivity and reduce costs. Get More Uniform Peak Heights, Improved Accuracy...
Catalog: 4337457
Size: 5000 reactions
Size: 5000 reactions
The Covaris® M220 Focused-ultrasonicator™ is designed for next generation sequencing applications that require high-quality DNA fragmentation for library preparation. The Covaris® M220 efficiently focuses the minimum amount of energy required directly into a sample, enabling precise control of the hydrodynamic shearing forces that fragment nucleic acids to the selected size. The process is isothermal, so fragmentation is unbiased, the sample is undamaged, and yields are high. The Covaris® focused-ultrasonic technology is considered a DNA shearing standard in many labs worldwide. The Covaris® M...
Catalog: 4482277
Size: 1 instrument
Size: 1 instrument
The Ion AmpliSeq™ RNA Library Kit is a library construction kit designed for rapid preparation of RNA amplicon libraries compatible with Ion AmpliSeq™ RNA ready-to-use or custom panels for sequencing on the Ion Personal Genome Machine® (PGM™) or Ion Proton™ system. A list of TaqMan® assays corresponding to the same gene regions interrogated by Ion AmpliSeq™ RNA amplicons can be found at www.lifetechnologies.com/confirmrna . Key Features: • Accurately measure gene expression fold changes from Ion AmpliSeq™ RNA panels • Start with as little as 500 pg of unfixed RNA or 5 ng of FFPE RNA • Ion Ampl...
Catalog: 4482752
Size: 384 reactions
Size: 384 reactions
SeqSphere+ Software from Ridom allows for automatic processing and analyzing of microbial sequence data obtained from Ion Torrent™ systems. SeqSphere+ Software enables whole genome microbial typing (MLST+), traditional MLST, or 16S rDNA sequencing projects. This software is designed both for individual labs and for distributed work-groups (client/server model) to enable easy data sharing. License options are available for 1, 3, or 5 years; 2 or 5 seats; and commercial or academic/government labs. Ridom SeqSphere+ Software Features: • User-friendly: no scripting skills or bioinformatician neede...
Catalog: 4483702
Size: 1 each
Size: 1 each
The 7900HT TaqMan® Array Upgrade enables you to run the TaqMan® Arrays – a microfluidic card – on your Applied Biosystems 7900HT Fast Real-Time PCR System. This upgrade gives you access to an efficient, easy-to-use tool that eliminates labor-intensive pipetting steps and enables high throughput gene expression results using the gold-standard 5' nuclease TaqMan® Assay technology. • Convenience – includes everything you need to run the 7900HT TaqMan® Array on your 7900HT system • Success – highly trained service engineers will install and test your 7900HT TaqMan® Array Upgrade to get you up and ...
Catalog: 4329012
Size: 1 kit
Size: 1 kit
This is a workgroup license for Vector NTI® Express Designer that serves up to 50 users who wish to share their data with each other. This license requires an Advanced Support Agreement (A15336). Vector NTI® Express Designer takes you beyond traditional sequence analysis and design and into the new frontier of rational bio-design. Vector NTI® Express Designer was designed for synthetic biology, metabolic engineering, genetic engineering, and molecular biology professionals who want to rationally design, characterize, assemble, re-factor, and reuse genetic "parts," "devices," and "circuits"—ult...
Catalog: A15335
Size: 1 each
Size: 1 each
The Pippin Prep™ System is a small tabletop instrument that automates the size selection and collection of DNA for PGM™ sequencer libraries. Simply enter the desired base-pair target range via the software interface and after a 1.5 hr run the system will yield the programmed DNA fractions with virtually no low molecular weight contamination. The tight fragment size distributions obtained provide a more uniform template for amplification. And the processing of samples is simplified through the use of disposable pre-cast agarose gel cassettes. Benefits of the Pippin Prep™ System • Time savings c...
Catalog: 4471271
Size: 1 each
Size: 1 each
SeqSphere+ Software from Ridom allows for automatic processing and analyzing of microbial sequence data obtained from Ion Torrent™ systems. SeqSphere+ Software enables whole genome microbial typing (MLST+), traditional MLST, or 16S rDNA sequencing projects. This software is designed both for individual labs and for distributed work-groups (client/server model) to enable easy data sharing. License options are available for 1, 3, or 5 years; 2 or 5 seats; and commercial or academic/government labs. Ridom SeqSphere+ Software Features: • User-friendly: no scripting skills or bioinformatician neede...
Catalog: 4483698
Size: 1 each
Size: 1 each
SeqSphere+ Software from Ridom allows for automatic processing and analyzing of microbial sequence data obtained from Ion Torrent™ systems. SeqSphere+ Software enables whole genome microbial typing (MLST+), traditional MLST, or 16S rDNA sequencing projects. This software is designed both for individual labs and for distributed work-groups (client/server model) to enable easy data sharing. License options are available for 1, 3, or 5 years; 2 or 5 seats; and commercial or academic/government labs. Ridom SeqSphere+ Software Features: • User-friendly: no scripting skills or bioinformatician neede...
Catalog: 4483700
Size: 1 each
Size: 1 each
The Applied Biosystems® GeneAmp® PCR System 9700 is specifically designed for reliable PCR. The GeneAmp® PCR System 9700 consists of a base module and one of many interchangeable sample block modules. The Dual 96-Well GeneAmp® PCR System 9700 is designed for use with 0.2 mL reaction tubes or 96-well reaction plates for high-throughput PCR, cloning, and cycle sequencing applications. • Request a Demo Key Highlights: • Compact design maximizes bench space • Two 96-well sample blocks for high-throughput applications • Interchangeable sample block modules for greater flexibility • Graphical user i...
Catalog: 4343176
Size: 1 instrument
Size: 1 instrument
The Bioruptor® UCD-200 is a benchtop sonication device used to uniformly process up to 12 x 0.5 ml samples simultaneously in sealed tubes without aerosol formation. Consisting of a high-power ultrasound generating element located below a water bath, the Bioruptor® sonicates at a 20 kHz frequency, similar to a probe sonicator. The Bioruptor® comes with standard 0.5 ml accessories and the BioBox-200 for soundproofing. The Bioruptor® UCD-200 Provides: • Parallel processing of up to 12 DNA samples • Robust and reproducible results • Automated sample prep Get Reproducible DNA Shearing Easily and Au...
Catalog: 4465622
Size: 1 each
Size: 1 each
uTYPE® Dx SBT Analysis Software and support manual is provided as a CD. It is used to produce in vitro diagnostic human leukocyte antigen (HLA) typing results from data generated by the 3500 Dx Genetic Analyzer CS2 instruments. Features include: • Processes .ab1 files from the 3500 Dx Genetic Analyzer CS2 instruments (8 and 24 capillary) • Used to produce in vitro diagnostic (IVD)-labeled results • Imports the uTYPE® Dx Allele Library, an allele variant sequence database This software compares data produced by the genetic analyzer to the allele library (variant database) and outputs sample HLA...
Catalog: 539993
Size: 1 CD
Size: 1 CD
Ambion® Custom In Vivo Ready synthesized siRNA, 10 µmol. These siRNAs are subjected to that extra level of purification and testing required for the introduction of high quality siRNAs into animals.
Catalog: AM16233
Size: 10 µmol
Size: 10 µmol
For Academic pricing please login or contact us at discoverysciences@invitrogen.com. The Tango™ CCR5- bla U2OS cells contain the human Chemokine (C-C Motif) Receptor 5 (CCR5) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR- bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin⁄TEV protease fusion protein and the beta-lactamase ( bla ) reporter gene under the control of a UAS response element. The Tango™ CCR5- bla U2OS cells are functionally validated for Z' and EC 50 concentrations of MIP-1a. In addition,...
Catalog: K1788
Size: 8 × 10^6 cells
Size: 8 × 10^6 cells
Activation of the heat shock response⁄unfolded protein response (HSR⁄UPR) occurs in response to a diversity of chemical, environmental, and physiological stress conditions. Transcriptional regulation of the human HSR is mediated by a family of three heat shock transcription factors (HSFs), HSF-1, -2, and -4. Stress-induced activation of quiescent HSF monomers results in their trimerization and accumulation in the nucleus, wherein they bind to and upregulate transcription of target genes (e.g. molecular chaperones, certain proteases, and other stress response genes) harboring a heat shock eleme...
Catalog: K1813
Size: 1 vial
Size: 1 vial
The CellSensor® NFκB-bla RAW264.7 mouse macrophage cell line contains a beta-lactamase reporter gene under control of a stably integrated NFκB response element. This cell line is a clonal population isolated in response to lipopolysaccharide by flow cytometry. This cell line has been tested for assay performance under variable conditions, including DMSO concentration, cell number, stimulation time, and substrate loading time, and has been validated for Zfi-factor and EC50 concentrations of the TLR7 ligand imiquimod. Additional data using alternate stimuli are shown. The molecules responsible f...
Catalog: K1673
Size: 1 vial
Size: 1 vial
Neurotrophins (NGF, BDNF, NT-3, and NT-4) and their transmembrane receptors (TrkA, TrkB, TrkC, and P75NTR) play important roles in the regulation of neuronal and non-neuronal cell proliferation, differentiation, survival, and death. Neurotrophin signaling also mediates higher-order neuronal activities, such as learning, memory, and behavior. Alterations in neurotrophin levels and their receptors have been implicated in neurodegenerative disorders, such as Alzheimer's disease and Huntington's disease, as well as psychiatric disorders. Neurotrophins propagate their signal through activating mult...
Catalog: K1491
Size: 1 vial
Size: 1 vial
The CellSensor™Myc- bla HCT116 cell line contains a beta-lactamase reporter gene under the control of Myc binding sequences. The construct was transduced into HCT116 cells using a lentiviral system. HCT116 is a colon cancer cell line which expresses a mutated form of beta-catenin. This form of beta-catenin leads to the accumulation of beta-catenin and constitutive activation of downstream genes such as Myc . This cell line is a clonal population isolated by flow cytometry. It has been validated for cell plating density and DMSO tolerance. The signaling pathway has been validated using RNAi aga...
Catalog: K1467
Size: 1 vial
Size: 1 vial
Jak/Stat signaling pathways play essential roles in the cellular responses to distinct cytokines. One of the Jak/Stat pathways, Jak2/Stat5, mediates cell proliferation in response to Interleukin - 3 (IL - 3), prolactin, erythropoietin (Epo), and granulocyte - macrophage colony stimulating factor (GM - CSF). JAK2 gene knockout causes embryonic lethality due to defective erythropoiesis, suggesting that the Jak2/Stat5 pathway plays an important role in red blood cell formation. The recent discovery of an activating mutation in JAK2 (V617F) present in a high percentage of myeloproliferative diseas...
Catalog: K1654
Size: 1 vial
Size: 1 vial
The CellSensor® Gli-bla NIH 3T3 Cell Line contains a beta-lactamase reporter gene under control of the Gli response element stably integrated into NIH 3T3 cells. This cell line is a clonal population isolated by flow cytometry in response to the mouse sonic hedgehog (mShh) ligand. This cell line has been tested for assay performance under variable conditions, including DMSO concentration, cell number, stimulation time, and substrate loading time, as well as validated for Z'-factor and EC50 concentrations of Shh. Additional data using known inhibitors or activators of the pathway have also been...
Catalog: K1642
Size: 1 vial
Size: 1 vial
LanthaScreen™ GFP Cellular Assays allow for the analysis of post-translational modifications for a number of target proteins in an live-cell context. The JAK2⁄STAT5 signaling pathway plays an essential role in blood cell formation in response to cytokines such as GM-CSF, IL-3, and EPO. The recent discovery of an activating mutation in JAK2 (V617F) present in high percentage of myeloproliferative disease (MPD) patients suggests that this mutant JAK2 activity is a potential therapeutic target for certain forms of MPD. The assay described in this summary makes use of a cell line engineered for ex...
Catalog: K1588
Size: 1 vial
Size: 1 vial
The CellSensor® LEF/TCF-bla SW480 cell line contains a beta-lactamase reporter gene under control of the lymphoid enhancer factor/T cell factor (LEF/TCF) consensus binding sequence stably integrated into SW480 cells, which express a truncated form of the tumor suppressor protein adenomatous polyposis coli (APC). This cell line is a clonal population isolated by flow cytometry, with the pathway validated using RNAi against beta-catenin. The truncated, loss-of-function version of APC expressed in this cell line prevents the proper assembly of the beta-catenin destruction complex. This results in...
Catalog: K1675
Size: 1 vial
Size: 1 vial
Wnt signaling via beta - catenin plays a central role in development and homeostasis. This pathway is invariably disrupted in colorectal tumors and commonly affected by mutation in other cancers. Binding of the Wnt protein to the Frizzled transmembrane receptors initiates a signaling cascade that activates the Dishevelled protein, which then inhibits the serine/threonine kinase Glycogen Synthase - 3 Beta (GSK - 3B). This signal leads to functional inactivation and dissociation of a multiprotein beta - catenin destruction complex made up of the tumor suppressor protein Adenomatous Polyposis Col...
Catalog: K1677
Size: 1 vial
Size: 1 vial
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease. • Increase disease relevance by interrogating a purified and active full-length LRRK2 protein • Uncover novel compounds or hits specific to the full-length form • Advan...
Catalog: A15202PT
Size: 1 mg
Size: 1 mg
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multi-domain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active wild type LRRK2 protein may be useful in research to better understand the native protein, unaffected by mutations, as well as to explore the mechanisms underlying the disease. • Increase disease relevance by interrogating a purified and active full-length LRRK2 protein • Uncover novel compounds or hits specific to the full-length form • Advance Parkinso...
Catalog: A15199PT
Size: 1 mg
Size: 1 mg
This is a workgroup license for Vector NTI® Express Designer that serves up to 10 users who wish to share their data with each other. This license requires an Advanced Support Agreement (A15333). Vector NTI® Express Designer takes you beyond traditional sequence analysis and design and into the new frontier of rational bio-design. Vector NTI® Express Designer was designed for synthetic biology, metabolic engineering, genetic engineering, and molecular biology professionals who want to rationally design, characterize, assemble, re-factor, and reuse genetic "parts," "devices," and "circuits"—ult...
Catalog: A15332
Size: 1 each
Size: 1 each
This sequencing buffer is optimized for use with BigDye® Terminator v1.1 and v3.1 Cycle Sequencing Kits. For Research Use Only. Not for use in diagnostics procedures.
Catalog: 4336701
Size: 233 ml
Size: 233 ml
DYRK3 belongs to the DYRK family of dual-specificity protein kinases that catalyze phosphorylation of serine⁄threonine and tyrosine residues. The members of this family share structural similarity, but differ in their substrate specificity, suggesting their involvement in different cellular functions.
Catalog: PV3998
Size: 1 mg
Size: 1 mg
Products from Bigdye® Terminator V3.1 Cycle Sequencing Kit to Dyrk3 Recombinant Human Protein
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