This purified rat GFAP monoclonal antibody is specific to the bovine, human, mouse and rat GFAP. Glial fibrillary acidic protein (GFAP) is a major structural component of astrocytes. GFAP monoclonal antibody can be used in applications such as western blotting, ELISA, flow cytometry, immunoblotting, immunohistochemistry, immunoprecipitation and immunofluorescence. Anti-GFAP monoclonal antibody recognizes the expressed product of the GFAP gene, also known as Gfap.

Antibody Specifications:

• Applications: Validated applications for this GFAP antibody are western blotting, flow cytometry, ELISA, immunoblotting, immunohistochemistry, immunoprecipitation, and immunofluorescence.
• Host Species and Isotype: The host species and isotype of this GFAP antibody is rat IgG2aκ.
• Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 2.2B10.
• Reactivity: Detects human, bovine, mouse, and rat GFAP
• Product Size: GFAP Monoclonal Antibody is available in a 100 µg pack size.

The 50 kDa type III intermediate filament protein glial fibrillary acidic protein (GFAP) is a major structural component of astrocytes. GFAP associates with the calcium binding protein annexin II-p2 and S-100. Association with these proteins together with phosphorylation regulates GFAP polymerization. Astrocytes respond to brain injury by proliferation (astrogliosis), and one of the first events to occur during astrocyte proliferation is increased GFAP expression. Interestingly, antibodies to GFAP have been detected in individuals with dementia.