This purified Mouse anti-ErbB-2 Monoclonal Antibody is specific to human, rat, and mouse ErbB2 (HER2). Over-expression of c-erbB-2 is observed in 15–40% of primary human breast tumors and correlates with poor prognosis in node positive breast cancer. Over-expression of c-erbB-2 is also observed in ovarian, gastric, salivary, and non-small cell lung carcinomas. Validated applications for mouse anti-ErbB-2 monoclonal antibody are immunoprecipitation, immunohistochemistry, flow cytometry, and Western blotting.
Antibody Attributes:
• Applications: Validated applications for Mouse anti-ErbB-2 monoclonal antibody are immunoprecipitation, immunohistochemistry, flow cytometry and Western blotting.
• Host Species and Isotype: The host species and isotype of the ErbB-2 monoclonal antibody is mouse IgG1.
• Clone ID of Monoclonal Antibody (mAb): The ErbB-2 monoclonal antibody clone is e2-4001.
• Reactivity: This ErbB-2 monoclonal antibody is specific to human, rat, and mouse ErbB2 (HER2).
• Product Size: ErbB-2 Monoclonal Antibody, Mouse (clone e2-4001) is available in a 100 µg pack size.
This antibody recognizes c-erbB-2, a receptor protein tyrosine kinase with Mr=185 kDa, which is also known as p185HER-2. c-erbB-2 is the cellular homolog of the neu oncogene. c-erbB-2 is comprised of an extracellular ligand binding domain, a single transmembrane domain, a tyrosine kinase domain, and a C terminal region which mediates signaling. c-erbB-2 forms heterodimers with other members of the EGF receptor family, such as c-erbB-1. In response to ligand binding, c-erbB-2 is autophosphorylated on five tyrosine residues at its C terminus, producing docking sites for SH2-domain containing proteins such as phospholipase Cγ, PI3-K, Src, CHK, and others.
Over-expression of c-erbB-2 is observed in 15–40% of primary human breast tumors and correlates with poor prognosis in node positive breast cancer. Over-expression of c-erbB-2 is also observed in ovarian, gastric, salivary, and non-small cell lung carcinomas.
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![Schematic ErbB-2 ...](javascript: toggle("http://tools.invitrogen.com/content/sfs/gallery/high/ErbB-2-schematic.jpg","Schematic ErbB-2 Protein.","ErbB-2 (also known as Her-2 or neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. ErbB-2 forms complexes with other members of the EGFR receptor family. Binding of growth factors to these related receptors leads to phosphorylation on several tyrosine residues within the cytoplasmic domain of ErbB-2, thus activating the receptor. A direct link between overexpression of ErbB-2 in breast and ovarian cancers, which account for one-third of all cancers in women and approximately one-quarter of cancer-related deaths in females, has been shown in the literature. In addition, overexpression or abnormal activation of ErbB-2 has been found in a variety of tumors including brain, lung, prostate and skin cancer.");)
