This is a purified mouse anti-human SETD2 monoclonal antibody (mAb) that can be used in the validated application of immunoprecipitation (IP).

Recombinant antibody characteristics include:

• APPLICATIONS: This SETD2 mouse recombinant mAb has been validated for use in IP.
• HOST SPECIES AND ISOTYPE: This is a recombinant mouse monoclonal IgG1 antibody against human SETD2.
• PRODUCT SIZE: 100 µg

Specific for SETD2

SETD2 (SET domain containing 2) is a histone methyltransferase that methylates lysine-36 of histone H3. Methylation of lysine-36 of histone H3 is a specific tag for epigenetic transcriptional activation. SETD2 probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. SETD2 also binds DNA at promoters, and it may also act as a transcription activator that binds to promoters. In case of infection, SETD2 binds to the promoters of adenovirus 12 E1A gene, which possibly leads to its regulated expression.

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