This is a purified mouse anti-human CBX4 monoclonal antibody (mAb) that can be used in the validated applications such as immunoprecipitation (IP).

Recombinant antibody characteristics include:

• APPLICATIONS: This CBX4 mouse recombinant mAb has been validated for use in IP.
• HOST SPECIES AND ISOTYPE: This is a recombinant mouse monoclonal IgG1 antibody against human CBX4.
• PRODUCT SIZE: 100 µg

Specific for CBX4

CBX4 (chromobox protein homolog 4) is a protein that in humans is encoded by the CBX4 gene. This is E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. As a component of a Polycomb group (PcG) multiprotein PRC1-like complex, CBX4 is member of a complex class required to maintain the transcriptionally repressive state of many genes throughout development including Hox genes. CBX4 is involved in the sumoylation of HNRNPK, which is a p53/ TP53 transcriptional coactivator. Hence, it indirectly regulates p53/ TP53 transcriptional activation resulting in p21/ CDKN1A expression.

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