This mouse anti-human TNKS1 monoclonal antibody can be used in the validated application of immunoprecipitation (IP).

Antibody characteristics include:

• APPLICATIONS: TNKS1 Monoclonal Antibody, Recombinant Biotinylated Fab is validated for use in immunopreciptation.
• HOST SPECIES AND ISOTYPE: This is a recombinant mouse monoclonal biotinylated Fab of human TNKS1.
• PRODUCT SIZE: 100 µg

Specific for TNKS1

TNKS1 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase) is a poly-ADP-ribosyltransferase involved in various processes. Human tankyrases post-translationally modifies multiple proteins involved in telomere length maintenance, sister telomere association, spindle assembly, trafficking of glut4-containing vesicles, and insulin responsiveness. Recently tankyrases have shown to be involved in the Wnt signaling pathway, which at the heart of this pathway is the beta-catenin destruction complex. Tankyrases bind directly to axin, which is a member of the destruction complex involved in beta-catenin degradation. Inhibition of tankyrase stabilizes axin, increases the activity of the destruction complex, and promotes degradation of beta-catenin. Thus, tankyrases are an attractive target anticancer therapies.

Related Links:

Learn more about the superior performance of ABfinity™ recombinant monoclonal antibodies.

See Life Technologies' full line of ABfinity™ recombinant monoclonal antibodies.